Abstract
ABRIN, a protein present in the seeds of Abrus precatorius L. (Leguminosae), is highly toxic in animals and man, especially when administered parenterally1–3. We show here that abrin is a potent inhibitor of peptide chain elongation although the precise point at which the compound acts has not been determined. Recently we found that ricin, a toxic protein present in the seeds of an entirely different plant (Ricinus communis L. (Euphorbiaceae)), inhibits protein synthesis in a similar fashion4.
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Hellin, H., thesis, Universität zu Dorpat (1891).
Elfstrand, M., thesis, Uppsala University (1897).
Hausmann, W., Beitr. Chem. Physiol. Pathol., 2, 134 (1902).
Olsnes, S., and Pihl, A., FEBS Letters, 20, 327 (1972).
Lin, J.-Y., Lei, L.-L., and Tung, T.-C., J. Formosean Med. Ass., 68, 518 (1969).
Olsnes, S., European J. Biochem., 15, 464 (1970).
Olsnes, S., European J. Biochem., 23, 557 (1971).
Lin, J.-Y., Tserng, K.-Y., Chen, C.-C., Lin, L.-T., and Tung, T.-C., Nature, 227, 292 (1970).
Lingrel, J. B., in Methods in Protein Biosynthesis (edit. by Laskin, A. E., and Last, J. A.), 2, 231 (Marcel Decker, New York, 1972).
Henseval, M., La Cellule, 17, 141 (1900).
Lin, J.-Y., Kao, W.-Y., Tserng, K.-Y., Chen, C.-C., and Tung, T.-C., Cancer Research, 30, 2431 (1970).
Grollman, A. P., and Stewart, M. L., Proc. US Nat. Acad. Sci., 61, 719 (1968).
Hoerz, W., and McCarty, K. S., Biochem. Biophys. Acta, 228, 526 (1971).
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OLSNES, S., PIHL, A. Inhibition of Peptide Chain Elongation. Nature 238, 459–461 (1972). https://doi.org/10.1038/238459a0
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DOI: https://doi.org/10.1038/238459a0
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