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How lac Repressor Binds to DNA

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Abstract

A sequence of about fifty amino-acids at the N-terminus of the lac repressor is thought to bind directly to lac operator DNA. Although this length cannot make the conventional cleft, it could form a protrusion; the manner in which such a protrusion interacts with the DNA site is discussed here.

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Author notes

  1. A. KLEMM: Deceased March 13, 1972

Authors and Affiliations

  1. Institute für Genetik, Universität zu Köln, 5 Köln-Lindenthal, Weyertal, 121, W. Germany

    K. ADLER, K. BEYREUTHER, E. FANNING, N. GEISLER, B. GRONENBORN, A. KLEMM, B. MÜLLER-HILL, M. PFAHL & A. SCHMITZ

Authors
  1. K. ADLER
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  2. K. BEYREUTHER
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  3. E. FANNING
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  4. N. GEISLER
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  5. B. GRONENBORN
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  6. A. KLEMM
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  7. B. MÜLLER-HILL
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  8. M. PFAHL
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  9. A. SCHMITZ
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ADLER, K., BEYREUTHER, K., FANNING, E. et al. How lac Repressor Binds to DNA. Nature 237, 322–327 (1972). https://doi.org/10.1038/237322a0

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  • DOI: https://doi.org/10.1038/237322a0

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