Abstract
DPG has a two-fold effect on human deoxyhaemoglobin. It both stabilizes and slightly distorts the S form, and may therefore affect the solubility.
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References
Benesch, R., and Benesch, R. E., Biochem. Biophys. Res. Commun., 26, 162 (1967).
Chanutin, A., and Curnish, R. R., Arch. Biochem. Biophys., 121, 96 (1967).
Benesch, R., Benesch, R. E., and Yu, C. I., Proc. US Nat. Acad. Sci., 59, 526 (1968).
Benesch, R., Benesch, R. E., and Enoki, Y., Proc. US Nat. Acad. Sci., 61, 1102 (1968).
Bunn, H. F., and Briehl, R. W., J. Clin. Invest., 49, 1088 (1970).
Tomita, S., and Riggs, A., J. Biol. Chem., 246, 547 (1971).
Caldwell, P. R. B., Nagel, R. L., and Jaffé, E. R., Biochem. Biophys. Res. Commun., 44, 1504 (1971).
Perutz, M. F., Nature, 228, 734 (1970).
Muirhead, H., and Greer, J., Nature, 228, 516 (1970).
Perutz, M. F., J. Cryst. Growth, 2, 54 (1968).
Benesch, R. E., Benesch, R., and Yu, C. I., Biochemistry, 8, 2567 (1969).
Bragg, W. L., and Perutz, M. F., Acta Cryst., 5, 277 (1952).
Monod, J., Wyman, J., and Changeux, J. P., J. Mol. Biol., 12, 88 (1965).
Bunn, H. F., Science, 172, 1049 (1971).
Bailey, J. F., Beetlestone, J. G., and Irvine, D. H., J. Chem. Soc., A, 5, 756 (1970).
Riggs, A., Proc. US Nat. Acad. Sci., 68, 2062 (1971).
Carami, A., and Manning, J. M., Proc. US Nat. Acad. Sci., 68, 1180 (1971).
Murayama, M., Olson, R. A., and Jenning, W. H., Biochim. Biophys. Acta, 94, 194 (1965).
Beutler, E., Blood (in the press).
Kilmartin, J. V., and Rossi-Benardi, L., Nature, 222, 1243 (1969).
Preutz, M. F., New Scientist, 50, 762 (1971).
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ARNONE, A. X-ray Diffraction Study of Binding of 2,3-Diphosphoglycerate to Human Deoxyhaemoglobin. Nature 237, 146–149 (1972). https://doi.org/10.1038/237146a0
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DOI: https://doi.org/10.1038/237146a0
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