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Stimulus Characteristics of Marihuana Components

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Abstract

THE effects of certain drugs are sufficiently strong and distinctive for animals to learn differential responses solely on the basis of whether they are in the drug or control condition1. Tests with lower doses of the same drug can establish the threshold for this discriminative response, and tests with other compounds can be used to determine the similarity or dissimilarity of their subjective effects. We have used this method for characterizing the pharmacological actions of Δ1-tetrahydrocannabinol (Δ1-THC), which is reported to be the major psychoactive constituent of marihuana2–3.

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References

  1. Overton, D. A., in Psychopharmacology: A Review of Progress 1957–1967 (edit. by Efron, D. H.). Public Health Service Publication No. 1836, 918 (US Government Printing Office, Washington DC, 1968).

    Google Scholar 

  2. Mechoulam, R., Science, 168, 1159 (1970).

    Article  ADS  CAS  Google Scholar 

  3. Isbell, H., Gorodetzsky, C. W., Jasinski, D., Claussen, V., v. Spulak, F., and Korte, F., Psychopharmacologia, 11, 184 (1967).

    Article  CAS  Google Scholar 

  4. Kubena, R. K., and Barry, H., III, J. Pharmacol. Exp. Therap., 173, 94 (1970).

    CAS  Google Scholar 

  5. Kubena, R. K., Perhach, jun., J. L., and Barry, H., III, Europ. J. Pharmacol., 14, 89 (1971).

    Article  CAS  Google Scholar 

  6. Kubena, R. K., and Barry, H., III, J. Pharm. Sci., 58, 99 (1969).

    Article  CAS  Google Scholar 

  7. Kubena, R. K., and Barry, H., III, Psychopharmacologia, 15, 196 (1969).

    CAS  PubMed  Google Scholar 

  8. Gill, E. W., Paton, W. D. M., and Pertwee, R. G., Nature, 228, 134 (1970).

    Article  ADS  CAS  Google Scholar 

  9. Sofia, R. D., and Barry, H., III, Europ. J. Pharmacol., 13, 134 (1970).

    Article  CAS  Google Scholar 

  10. Mechoulam, R., Shani, A., Edery, H., and Grunfield, Y., Science, 169, 611 (1970).

    Article  ADS  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Pharmacology, University of Pittsburgh School of Pharmacy, Pittsburgh, Pennsylvania, 15213

    ROBERT K. KUBENA & HERBERT BARRY III

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  1. ROBERT K. KUBENA
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  2. HERBERT BARRY III
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KUBENA, R., BARRY, H. Stimulus Characteristics of Marihuana Components. Nature 235, 397–398 (1972). https://doi.org/10.1038/235397a0

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  • DOI: https://doi.org/10.1038/235397a0

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