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Lymphocyte Sensitization to Basic Protein of Brain in Malignant Neoplasia: Experiments with Serotonin and Related Compounds

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Abstract

IT has been found that blood lymphocytes from patients suffering from malignant neoplasia (even in an early stage) are sensitized to a basic protein1 (encephalitogenic factor, EF) derived from human brain2. They react even more markedly (but to a strikingly similar degree) with a basic protein derived from a variety of human tumours3. During a visit to Dr Carnegie's laboratory some months ago one of us (E. J. F.) was shown the complementary structure of the serotonin molecule and the antigenic determinant (since published4) and realized that since the electrophoretic method1 depends on interaction of EF with sensitized lymphocytes, structures complementary to the EF determinant might be able to mask it and so block the reaction.

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References

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Authors and Affiliations

  1. MRC Demyelinating Diseases Unit, Newcastle General Hospital, Westgate Road, Newcastle upon Tyne, NE4 6BE

    E. J. FIELD, E. A. CASPARY & P. R. CARNEGIE

Authors
  1. E. J. FIELD
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  2. E. A. CASPARY
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  3. P. R. CARNEGIE
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FIELD, E., CASPARY, E. & CARNEGIE, P. Lymphocyte Sensitization to Basic Protein of Brain in Malignant Neoplasia: Experiments with Serotonin and Related Compounds. Nature 233, 284–286 (1971). https://doi.org/10.1038/233284a0

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  • DOI: https://doi.org/10.1038/233284a0

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