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Monosodium Glutamate induces Convulsive Disorders in Rats

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Abstract

THE physiological and pharmacological effects of L-glutamate have received much attention since its implication in the aetiology of the “Chinese restaurant syndrome”1–3. Although an excess of L-glutamic acid (GA) as the monosodium salt (MSG) was known to cause retinopathy in experimental animals4–7, brain lesions have been noticed only recently8–10. There seems to be no agreement about its pharmacological and neurophysiological effects in humans11 and experimental animals12.

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References

  1. Schaumburg, H. H., and Byck, R., New Engl. J. Med., 279, 105 (1968).

    Article  CAS  Google Scholar 

  2. Ambos, M., Leavitt, N. R., Marmorek, L., and Wolschina, S. B., New Engl. J. Med., 279, 105 (1968).

    Article  Google Scholar 

  3. Schaumburg, H. H., Byck, R., Gerstl, R., and Mashman, J. H., Science, 163, 826 (1969).

    Article  ADS  CAS  Google Scholar 

  4. Lucas, D. R., and Newhouse, J. P., Amer. Med. Assoc. Arch. Ophthalmol., 58, 193 (1957).

    Article  CAS  Google Scholar 

  5. Potts, A. M., Modrell, R. W., and Kingsbury, C., Amer. J. Ophthalmol., 50, 900 (1960).

    Article  CAS  Google Scholar 

  6. Freedman, J. K., and Potts, A. M., Invest. Ophthalmol., 1, 118 (1962).

    CAS  PubMed  Google Scholar 

  7. Olney, J. W., J. Neuropathol. Exp. Neurol., 28, 455 (1969).

    Article  CAS  Google Scholar 

  8. Olney, J. W., Science, 164, 719 (1969).

    Article  ADS  CAS  Google Scholar 

  9. Olney, J. W., and Sharpe, L. G., Science, 166, 386 (1969).

    Article  ADS  CAS  Google Scholar 

  10. Olney, J. W., and Ho, O., Nature, 227, 609 (1970).

    Article  ADS  CAS  Google Scholar 

  11. Morselli, P. L., and Garattini, S., Nature, 227, 611 (1970).

    Article  ADS  CAS  Google Scholar 

  12. Adamo, N. J., and Ratner, A., Science, 169, 673 (1970).

    Article  ADS  CAS  Google Scholar 

  13. Bhagavan, H. N., Coursin, D. B., and Dakshinamurti, K., Arch. Biochem. Biophys., 110, 422 (1965).

    Article  CAS  Google Scholar 

  14. Bhagavan, H. N., Maruyama, H., and Coursin, D. B., Abstr. Seventh Intern. Cong. Biochem., Tokyo, 802 (1967).

    Google Scholar 

  15. Bhagavan, H. N., Coursin, D. B., and Stewart, C. N., Life Sci., 8, 299 (1969).

    Article  CAS  Google Scholar 

  16. Wiechert, P., and Herbst, A., J. Neurochem., 13, 59 (1966).

    Article  CAS  Google Scholar 

  17. Wiechert, P., and Göllnitz, G., J. Neurochem., 15, 1265 (1968).

    Article  CAS  Google Scholar 

  18. Wiechert, P., and Göllnitz, G., J. Neurochem., 17, 137 (1970).

    Article  CAS  Google Scholar 

  19. Elliot, K. A. C., and van Gelder, N. M., J. Neurochem., 3, 28 (1958).

    Article  Google Scholar 

  20. Kamrin, R. P., and Kamrin, A. A., J. Neurochem., 6, 219 (1961).

    Article  CAS  Google Scholar 

  21. Roberts, E., Rothstein, M., and Baxter, C. F., Proc. Soc. Exp. Biol. Med., 97, 796 (1958).

    Article  CAS  Google Scholar 

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BHAGAVAN, H., COURSIN, D. & STEWART, C. Monosodium Glutamate induces Convulsive Disorders in Rats. Nature 232, 275–276 (1971). https://doi.org/10.1038/232275a0

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  • DOI: https://doi.org/10.1038/232275a0

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