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Oxytocin Antibody and Lactation and Parturition in Rats

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Abstract

To show that a hormone is essential to a particular Physiological process it is best to study an isolated deficiency state, but this has so far been difficult for oxytocin. Hypophysectomy, lesions in the hypothalamus and the administration of drugs—the experimental methods used so far—cannot produce a unihormonal deficiency with certainty, with the result that there persist differences of opinion about the role of oxytocin in the initiation and maintenance of lactation and parturition1,2. Oxytocin antibody of high titre and affinity3 provides, however, a new tool for these studies.

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References

  1. Benson, G. K., and Fitzpatrick, R. J., in The Pituitary Gland, 3 (edit by Harris, G. W., and Donovan, B. T.), 414 (University of California Press, 1966).

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  2. Fitzpatrick, R. J., The Pituitary Gland, 3 (edit. by Harris, G. W., and Donovan, B. T.), 453 (University of California Press, 1966).

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  3. Glick, S. M., Wheeler, M., Kagan, A., and Kumaresan, P., in Pharmacology of Hormonal Polypeptides and Proteins (edit. by Back, N., Martini, L., and Paoletti, R.), 93 (Plenum, New York, 1968).

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  4. Bisset, G. W., in Neurohypophyseal Hormones and Similar Polypeptides (edit. by Berde, B.), 475 (Springer, Berlin, 1968).

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  5. Berde, B., and Boissonnas, R. A., in Neurohypophyseal Hormones and Similar Polypeptides (edit. by Berde, B.), 802 (Springer, Berlin, 1968).

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Authors and Affiliations

  1. Coney Island Hospital, Brooklyn, New York, 11235

    P. KUMARESAN, A. KAGAN & S. M. GLICK

Authors
  1. P. KUMARESAN
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  2. A. KAGAN
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  3. S. M. GLICK
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KUMARESAN, P., KAGAN, A. & GLICK, S. Oxytocin Antibody and Lactation and Parturition in Rats. Nature 230, 468–469 (1971). https://doi.org/10.1038/230468a0

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  • DOI: https://doi.org/10.1038/230468a0

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