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Adverse Influence of Ozone on Pulmonary Bactericidal Activity of Murine Lung

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Abstract

As an air pollutant, ozone is considered to be an important predisposing factor in pulmonary bacterial infections1–2. Little is known about the precise mechanisms responsible for the diminished resistance to infection, but it seems that the pathogenesis of these infections involves inhibition of pulmonary antibacterial activity. In vivo investigations have demonstrated that mice exposed to ozone have an increased mortality from infection with pathogenic streptococci3 or K. pneumoniae2,4. Experiments using an in vitro method for measuring alveolar macrophage function have shown marked impairment in phagocytic activity after exposure of mice to ozone5. These results prompted us to study the effect of ozone on the in vivo rate of bacterial killing by the murine lung. We show inhibition of pulmonary bactericidal activity from short term exposures to ozone concentrations as low as 0.62 p.p.m.

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References

  1. Stokinger, H. E., Arch. Environ. Hlth, 10, 719 (1965).

    Article  CAS  Google Scholar 

  2. Purvis, M. R., Miller, S., and Ehrlich, R., J. Inf. Dis., 109, 238 (1961).

    Article  CAS  Google Scholar 

  3. Coffin, D. L., and Blommer, E. J., J. Air Poll. Cont. Assoc., 15, 523 (1965).

    Article  CAS  Google Scholar 

  4. Miller, S., and Ehrlich, R., J. Inf. Dis., 103, 145 (1958).

    Article  CAS  Google Scholar 

  5. Coffin, D. L., Gardner, D. E., Holzman, R. S., and Wolock, F. S., Arch. Environ. Hlth, 16, 633 (1968).

    Article  CAS  Google Scholar 

  6. Green, G. M., and Goldstein, E., J. Lab. Clin. Med., 68, 669 (1966).

    CAS  PubMed  Google Scholar 

  7. Green, G. M., and Kass, E. H., J. Exp. Med., 119, 167 (1964).

    Article  CAS  Google Scholar 

  8. Green, G. M., and Kass, E. H., J. Clin. Invest., 43, 769 (1964).

    Article  CAS  Google Scholar 

  9. Goldstein, E., and Green, G. M., J. Lab. Clin. Med., 68, 531 (1966).

    CAS  PubMed  Google Scholar 

  10. Goldstein, E., Green, G. M., and Seamans, C. S., J. Lab. Clin. Med., 75, 912 (1970).

    CAS  PubMed  Google Scholar 

Download references

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Authors and Affiliations

  1. Department of Internal Medicine, School of Medicine, and Department of Anatomy, School of Veterinary Medicine, University of California, Davis, California, 95616

    E. GOLDSTEIN, W. S. TYLER, P. D. HOEPRICH & C. EAGLE

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  1. E. GOLDSTEIN
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  2. W. S. TYLER
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  3. P. D. HOEPRICH
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  4. C. EAGLE
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GOLDSTEIN, E., TYLER, W., HOEPRICH, P. et al. Adverse Influence of Ozone on Pulmonary Bactericidal Activity of Murine Lung. Nature 229, 262–263 (1971). https://doi.org/10.1038/229262a0

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  • DOI: https://doi.org/10.1038/229262a0

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