Abstract
Comparison of the amino-acid sequence of the bacterial α-lytic protease with the mammalian pancreatic proteases shows homologies in the regions of the N-terminus, the single histidine, an aspartic acid residue, the active serine, and in the positions of the three disulphide bridges. The partial sequence of a trypsin-like enzyme from Streptomyces griseus provides further evidence for divergent evolution of this class of enzymes from a common ancestral gene.
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OLSON, M., NAGABHUSHAN, N., DZWINIEL, M. et al. Primary Structure of α-Lytic Protease: a Bacterial Homologue of the Pancreatic Serine Proteases. Nature 228, 438–442 (1970). https://doi.org/10.1038/228438a0
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