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A Ligand Exclusion Theory of Allosteric Effects

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Abstract

Cooperative and allosteric effects are explained by a theory involving not conformational changes but steric exclusion through interactions between multifunctional ligands which bind to common and topologically distinct subsites.

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Authors and Affiliations

  1. Veterans Administration Hospital, 4801 Linwood Boulevard, Kansas City, Missouri, 64128

    HARVEY F. FISHER, RONALD E. GATES & DALLAS G. CROSS

Authors
  1. HARVEY F. FISHER
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  2. RONALD E. GATES
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  3. DALLAS G. CROSS
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FISHER, H., GATES, R. & CROSS, D. A Ligand Exclusion Theory of Allosteric Effects. Nature 228, 247–249 (1970). https://doi.org/10.1038/228247a0

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  • DOI: https://doi.org/10.1038/228247a0

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