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Inhibitory Action of the Amygdala on the Lateral Hypothalamic Area in Rats

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Abstract

THE mammalian lateral hypothalamic area (LH) and the ventromedial hypothalamic nucleus (VMH) are involved in feeding and satiety function, respectively1. There is also reciprocity of electrical activity between the two2. Anatomically related to these areas, the amygdala has been shown to be involved in the same functions. Lesions of the basolateral nucleus of the amygdala results in hyperphagia3, while its electrical stimulation arrests feeding behaviour4. The stimulation of the amygdala also produces changes in the spontaneous discharge pattern of LH units, suggesting an inhibition or an activation–inhibition sequence between the LH and the amygdala5,6. We report here evidence that the inhibitory effect of the amygdala on the LH neurone is due to a long lasting inhibitory postsynaptic potential (IPSP) exerted through the stria terminalis.

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Authors and Affiliations

  1. Department of Physiology, Faculty of Medicine, Kanazawa University, Kanazawa, 920, Japan

    Y. OOMURA, T. ONO & H. OOYAMA

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  1. Y. OOMURA
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  2. T. ONO
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  3. H. OOYAMA
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OOMURA, Y., ONO, T. & OOYAMA, H. Inhibitory Action of the Amygdala on the Lateral Hypothalamic Area in Rats. Nature 228, 1108–1110 (1970). https://doi.org/10.1038/2281108a0

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