Abstract
IT has recently been reported that lysergic acid diethylamide-25 (LSD) has an inhibitory effect on T-maze learning in mice1. The animals were tested 2 min after an intraperitoneal injection of LSD, in view of the observations of Uyeno and Benson that the effect of LSD on agonistic behaviour approaches a maximum 5 min after injection2. Because of the controversy regarding potential long-term psychological effects of LSD, we had undertaken an examination of the effect on learning a shock avoidance task by repeated treatment of mice with increasing quantities of LSD over a long period. We report here the effect of this regimen on Y-maze learning in mice.
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References
Stasik, J. H., and Kidwell, J. F., Nature, 224, 1224 (1969).
Uyeno, E. T., and Benson, W. M., Psychopharmacologia, 7, 20 (1965).
Cardo, B., J. Physiol. (Paris), 53 (No. 3, Suppl. No. 1), 1 (1961).
Fischer, R. A., and Yates, F., Statistical Tables for Biological, Agricultural and Medical Research, 32 (Oliver and Boyd, London, 1948).
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MILLER, R., MILLER, E. Lack of a Long-term Effect of LSD on Y-maze Learning in Mice. Nature 228, 1107–1108 (1970). https://doi.org/10.1038/2281107a0
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DOI: https://doi.org/10.1038/2281107a0
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