Skip to main content

Advertisement

SpringerLink
Log in

Epstein–Barr Virus in Burkitt's Lymphoma and Nasopharyngeal Carcinoma: Antibodies to EBV associated Membrane and Viral Capsid Antigens in Burkitt Lymphoma Patients

  • Article
  • Published:

From Nature

View current issue Submit your manuscript

Abstract

Serological tests on 96 Burkitt lymphoma patients reveal antibody activity against virus-determined membrane antigen and viral capsid antigen while nucleic acid hybridization results on Burkitt's lymphoma and nasopharyngeal carcinoma add confirmatory evidence of an intimate association between the viral genome and the two diseases.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Klein, G., Clifford, P., Klein, E., and Stjernswärd, J., Proc. US Nat. Acad. Sci., 55, 1628 (1966).

    Article  ADS  CAS  Google Scholar 

  2. Klein, G., Clifford, P., Klein, E., and Stjernswärd, J., UICC Monog. Ser., 8, 209 (1967).

    Google Scholar 

  3. Klein, E., Clifford, P., Klein, G., and Hamberger, C. A., Intern. J. Cancer, 2, 27 (1967).

    Article  CAS  Google Scholar 

  4. Klein, G., Clifford, P., Klein, E., Smith, R. T., Minowada, J., Kourilsky, F. M., and Burchenal, J. H., J. Nat. Cancer Inst., 39, 1027 (1967).

    CAS  PubMed  Google Scholar 

  5. Klein, G., Pearson, G., Nadkarni, J. S., Nadkarni, J. J., Klein, E., Henle, G., Henle, W., and Clifford, P., J. Exp. Med., 128, 1011 (1968).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  6. Yata, J., and Klein, G., Intern. J. Cancer, 4, 767 (1969).

    Article  CAS  Google Scholar 

  7. Smith, R. T., Klein, G., Klein, E., and Clifford, P., Adv. Transplant., 779, 483 (1967).

    Google Scholar 

  8. Goldstein, G., Klein, G., Pearson, G., and Clifford, P., Cancer Res., 29, 749 (1969).

    CAS  PubMed  Google Scholar 

  9. Klein, G., Pearson, G., Henle, G., Henle, W., Goldstein, G., and Clifford, P., J. Exp. Med., 129, 697 (1969).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  10. Bremberg, S., Klein, G., and Epstein, A., Intern. J. Cancer, 4, 761 (1969).

    Article  CAS  Google Scholar 

  11. Henle, G., and Henle, W., J. Bacteriol., 91, 1248 (1966).

    CAS  PubMed  PubMed Central  Google Scholar 

  12. Henle, G., Henle, W., Clifford, P., Diehl, V., Kafuko, G. W., Kirya, B. G., Klein, G., Morrow, R. H., Munube, G. M. R., Pike, P., Tukei, P. M., and Ziegler, J. L., J. Nat. Cancer Inst., 43, 1147 (1969).

    CAS  PubMed  Google Scholar 

  13. Pearson, G., Klein, G., Henle, G., Henle, W., and Clifford, P., J. Exp. Med., 129, 707 (1969).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  14. Henle, W., and Henle, G., in Proc. Fourth Intern. Symp. Comparative Leukemia Research (Karger, Basel, in the press).

  15. Gerber, P., Whang-Peng, J., and Monroe, J. H., Proc. US Nat. Acad. Sci., 63, 740 (1969).

    Article  ADS  Google Scholar 

  16. Pearson, G., Dewey, F., Klein, G., Henle, G., and Henle, W., J. Nat. Cancer Inst. (in the press).

  17. Keller, J. M., Spear, P. G., and Roizman, B., Proc. US Nat. Acad. Sci., 65, 865 (1970).

    Article  ADS  CAS  Google Scholar 

  18. de Schryver, A., Friberg, jun., S., Klein, G., Henle, W., Henle, G., de Thé, G., Clifford, P., and Ho, H. C., Clin. Exp. Immunol., 5, 443 (1969).

    CAS  PubMed  PubMed Central  Google Scholar 

  19. Henle, W., Henle, G., Ho, H. C., Burtin, P., Cachin, Y., Clifford, P., de Schryver, A., de Thé, G., Diehl, V., and Klein, G., J. Nat. Cancer Inst., 44, 225 (1970).

    CAS  PubMed  Google Scholar 

  20. Old, L. J., Boyse, E. A., Oettgen, H. F., de Harven, E., Geering, G., Williamson, B., and Clifford, P., Proc. US Nat. Acad. Sci., 56, 1699 (1966).

    Article  ADS  CAS  Google Scholar 

  21. Old, L. J., Boyse, E. A., Geering, G., and Oettgen, H. F., Cancer Res., 28, 1288 (1968).

    CAS  PubMed  Google Scholar 

  22. Nadkarni, J. S., Nadkarni, J. J., Clifford, P., Manolov, G., Fenyö, E.-M., and Klein, E., Cancer, 23, 64 (1969).

    Article  CAS  PubMed  Google Scholar 

  23. Svedmyr, A., Demissie, A., Klein, G., and Clifford, P., J. Nat. Cancer Inst., 44, 595 (1970).

    CAS  PubMed  Google Scholar 

  24. Klein, G., Geering, G., Old, L. J., Henle, G., Henle, W., and Clifford, P., Intern. J. Cancer, 5, 185 (1970).

    Article  CAS  Google Scholar 

  25. Klein, G., Gergely, L., and Goldstein, G., Clin. Exp. Immunol. (in the press).

  26. Einhorn, N., Klein, G., and Clifford, P., Cancer (in the press).

Download references

Author information

Authors and Affiliations

  1. Institute for Tumour Biology, Karolinska Institutet, 104 01 Stockholm 60, Sweden

    PETER GUNVÉN & GEORGE KLEIN

  2. Virus Laboratories, The Children's Hospital of Philadelphia, Philadelphia, 19146, Pennsylvania

    GERTRUDE HENLE & WERNER HENLE

  3. Department of Head and Neck Surgery, Kenyatta National Hospital, PO Box 30024, Nairobi

    PETER CLIFFORD

Authors
  1. PETER GUNVÉN
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. GEORGE KLEIN
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. GERTRUDE HENLE
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. WERNER HENLE
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. PETER CLIFFORD
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

GUNVÉN, P., KLEIN, G., HENLE, G. et al. Epstein–Barr Virus in Burkitt's Lymphoma and Nasopharyngeal Carcinoma: Antibodies to EBV associated Membrane and Viral Capsid Antigens in Burkitt Lymphoma Patients. Nature 228, 1053–1056 (1970). https://doi.org/10.1038/2281053a0

Download citation

  • Received:

  • Revised:

  • Issue Date:

  • DOI: https://doi.org/10.1038/2281053a0

  • Springer Nature Limited

This article is cited by

Search

Navigation