Abstract
4-THIOURIDINE is a constituent of the tRNA of Escherichia coli1–3. It is located in a position where, according to the cloverleaf model, specific base pairing by hydrogen bonding is assumed not to occur. X-ray crystallographic4 and spectral analyses5 of the monomer and polymer nucleoside have been performed and 4-thiouridine is the first pyrimidine nucleoside that has been shown to exist in a syn conformation in the crystalline state. We now report studies on the molecular structure of the l-methyl-4-thiouracil.9-methyladenine complex.
Similar content being viewed by others
References
Lipsett, M. N., J. Biol. Chem., 240, 3975 (1965).
Lipsett, M. N., and Doctor, B. P., J. Biol. Chem., 242, 4072 (1967).
Lipsett, M. N., Norton, J. S., and Peterkofsky, A., Biochemistry, 6, 855 (1967).
Saenger, W., and Scheit, K. H., Angew. Chem., 81, 121 (1969).
Scheit, K. H., and Saenger, W., FEBS Letters, 2, 305 (1969).
Saenger, W., Suck, D., and Scheit, K. H., FEBS Letters, 5, 262 (1969).
Hoogsteen, K., Acta Cryst., 16, 907 (1963).
Haschemeyer, A. E. V., and Sobell, H. M., Acta Cryst., 18, 525 (1965).
Katz, L., Tomita, K., and Rich, A., Acta Cryst., 21, 754 (1966).
Mathews, F. S., and Rich, A., J. Mol. Biol., 8, 89 (1964).
Baklagina, J. G., Volkenstein, M. V., and Kondraschew, J. P., Zh. Strukt. Khim., 7, 399 (1966).
Donohue, J., J. Mol. Biol., 45, 231 (1969).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
SAENGER, W., SUCK, D. Biological Sciences: Molecular Structure of 1-Methyl-4-thiouracil.9-methyladenine: Unusual Base Pair in tRNA. Nature 227, 1046–1047 (1970). https://doi.org/10.1038/2271046a0
Received:
Issue Date:
DOI: https://doi.org/10.1038/2271046a0
- Springer Nature Limited