Abstract
Release factors R1 or R2 stimulate equally well the release of f2 coat protein, suggesting that UAA is the first coat terminator codon. The suppression of a nonsense codon can be regulated in vitro by the concentration of R factor of appropriate codon specificity.
Similar content being viewed by others
References
Capecchi, M. R., Proc. US Nat. Acad. Sci., 58, 1144 (1967).
Caskey, C. T., Tompkins, R., Scolnick, E., Caryk, T., and Nirenberg, M., Science, 162, 135 (1958).
Last, J. A., Stanley, W. M., Salas, M., Hille, M. B., Wahba, A. J., and Ochoa, S., Proc. US Nat. Acad. Sci., 57, 1062 (1967).
Scolnick, E., Tompkins, R., Caskey, T., and Nirenberg, M., Proc. US Acad. Sci., 61, 768 (1968).
Scolnick, E. M., and Caskey, C. T., Proc. US Nat. Acad. Sci., 64, 1235 (1969).
Caskey, T., Scolnick, E., Tompkins, R., Goldstein, J., and Milman, G., Cold Spring Harbor Symp. Quant. Biol., 34, 479 (1969).
Capecchi, M. R., and Klein, H. A., Cold Spring Harbor Symp. Quant. Biol., 34, 469 (1969).
Beaudet, A., Goldstein, J., Milman, G., Tompkins, R., Rosman, M., Scolnick, E., and Caskey, C. T., Fed. Proc., 29, 583 (1970) (Abst.).
Nichols, J. L., Nature, 225, 147 (1970).
Nathans, D., J. Mol. Biol., 13, 521 (1965).
Weber, K., and Konigsberg, W., J. Biol. Chem., 242, 8563 (1967).
Ganoza, M. C., and Nakamoto, T., Proc. US Nat. Acad. Sci., 55, 162 (1966).
Cuzin, F., Kretchmer, N., Greenberg, R. E., Hurwitz, R., and Chapeville, F., Proc. US Nat. Acad. Sci., 58, 2079 (1967).
Webster, R. E., Engelhardt, D. L., Zinder, N. D., and Konigsberg, W., J. Mol. Biol., 29, 27 (1967).
Roufa, D. J., Doctor, B. P., and Leder, P., Biochem. Biophys. Res. Commun. (in the press).
Rechler, M., and Martin, R. G., Nature, 226, 908 (1970).
Webster, R. E., and Zinder, N. D., J. Mol. Biol., 42, 425 (1969).
Newton, W. A., Beckwith, J. R., Zipser, D., and Brenner, S., J. Mol. Biol., 14, 290 (1965).
Yanofsky, C., and Ito, J., J. Mol. Biol., 21, 313 (1966).
Martin, R. G., Silbert, D. F., Smith, W. E., and Whitfield, jun., H. J., J. Mol. Biol., 21, 357 (1966).
Engelhardt, D. L., Webster, R. E., Wilhelm, R. C., and Zinder, N. D., Proc. US Nat. Acad. Sci., 54, 1791 (1965).
Gopinathan, K. P., and Garen, A., J. Mol. Biol., 47, 383 (1970).
Milman, G., Goldstein, J., Scolnick, E., and Caskey, T., Proc. US Nat. Acad. Sci., 63, 183 (1969).
Nirenberg, M. W., and Matthaei, J. H., Proc. US Nat. Acad. Sci., 47, 1588 (1961).
Muench, K. H., and Berg, P., in Procedures in Nucleic Acid Research, 375 (Harper and Row, New York, 1966).
Vogel, Z., Zamir, A., and Elson, D., Biochemistry, 8, 5161 (1969).
Chae, Y., Mazumder, R., and Ochoa, S., Proc. US Nat. Acad. Sci., 62, 1181 (1969).
Vinuela, E., Algranati, I. D., and Ochoa, S., Europ. J. Biochem., 1, 3 (1967).
Fromageot, H. P. M., and Zinder, N. D., Proc. US Nat. Acad. Sci., 61, 184 (1968).
Garen, A., Garen, S., and Wilhelm, R., J. Mol. Biol., 14, 167 (1965).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
BEAUDET, A., CASKEY, C. Release Factor Translation of RNA Phage Terminator Codons. Nature 227, 38–40 (1970). https://doi.org/10.1038/227038a0
Received:
Issue Date:
DOI: https://doi.org/10.1038/227038a0
- Springer Nature Limited
This article is cited by
-
The influence of the reading context upon the suppression of nonsense codons
Molecular and General Genetics MGG (1977)
-
The mechanism of peptide chain termination
Molecular and Cellular Biochemistry (1974)
-
In vivo translation of amber and ochre codons in Escherichia coli
Molecular and General Genetics MGG (1973)