Abstract
MOUSE thymus cells possess a high concentration of the theta (θ)1 and Ly2 antigens. Several approaches have demonstrated that the sensitivity of peripheral muriiie lymphocytes to the cytotoxic effect of θ and Ly antibodies is a thymus-dependent property. The population of cells sensitive to the cytotoxic effect of θ antibodies disappears from lymph nodes3 and spleen4 after neonatal thymectomy. Similarly, following neonatal thymectomy, the population of cells sensitive to Ly antibodies disappears from lymph nodes (unpublished results of M. S. and Yron). Following administration of heterologous anti-lymphocyte serum, a procedure resulting in elimination of thymus-dependent lymphocytes5,6, cells sensitive to θ antibodies disappear transiently from the lymph nodes7 and spleen4.
Similar content being viewed by others
References
Reif, A. E., and Allen, J. M. V., J. Exp. Med., 120, 413 (1964).
Boyse, E. A., Miyazawa, M., Aoki, T., and Old, L. J., Proc. Roy. Soc., B, 170, 175 (1968).
Schlesinger, M., and Yron, I., Israel J. Med. Sci., 5, 445 (1969).
Raff, M. C., Nature, 224, 378 (1969).
Turk, J. L., and Willoughby, D. A., Lancet, i, 249 (1967).
Leuchars, E., Wallis, V. J., and Davis, A. J. S., Nature, 219, 1325 (1968).
Schlesinger, M., and Yorn, I., Science, 164, 1412 (1969).
Zaalberg, O. B., Nature, 202, 1231 (1964).
Biozzi, G., Stiffel, C., Mouton, D., Bouthillier, Y., and Decreusefond, C., Immunology, 14, 7 (1968).
Shearer, G. M., and Cudcovicz, G., J. Immunol., 101, 1264 (1968).
Jerne, N. K., Nordin, A. A., and Henry, C., in Cell Bound Antibodies (edit. by Amos, B., and Koprowski, H.), 109 (Wistar Institute Press, Philadelphia, 1967).
Schlesinger, M., Cohen, A., and Hurvitz, D., Israel J. Med. Sci., 2, 616 (1966).
Greaves, M., and Möller, E., in Developmental Aspects of Antibody Formation and Structure (edit. by Sterzl, J.) (in the press).
Davies, A. J. S., Leuchars, E., Wallis, V., Marchant, R., and Elliott, E. V., Transplantation, 5, 222 (1967).
Mitchell, G. F., and Miller, J. F. A. P., J. Exp. Med., 128, 801 (1968).
Bach, J. F., and Antoine, B., Nature, 217, 658 (1968).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
SCHLESINGER, M. Anti-θ Antibodies for detecting Thymus-dependent Lymphocytes in the Immune Response of Mice to SRBC. Nature 226, 1254–1256 (1970). https://doi.org/10.1038/2261254a0
Received:
Issue Date:
DOI: https://doi.org/10.1038/2261254a0
- Springer Nature Limited
This article is cited by
-
Plaque-forming and rosette-forming cells in the spleen of NZB/BLN mice during ontogeny
Bulletin of Experimental Biology and Medicine (1974)
-
Properties of Educated T Cells for Rosette Formation and Cooperation with T Cells
Nature New Biology (1972)
-
Specificity of Anti-θ Sera in Cytotoxicity and Functional Tests on T Lymphocytes
Nature New Biology (1971)