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Inability of Plasma from Patients with Neoplasia to support Macrophage Recognition of Foreignness

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Abstract

THE involvement of the reticuloendothelial system (RES) in various disease processes is well documented, but the role of phagocytic promoting factors, or opsonins1–4, is still not clear. Opsonic depletion in animals—the so-called “blockade”5–8—has been shown to be associated with decreased immunogenicity9–11 and impaired resistance to infection12,13. Because tumour cells which possess tumour-specific antigens14 are, effectively, “non-self” it is possible that serum opsonic depletion might occur in the neoplastic patient. Phagocytic alterations have been found in patients with neoplasia15–18, but it is not known if these are attributable to a macrophage alteration or an opsonic defect.

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References

  1. Boyden, S., Intern. Rev. Exp. Path., 2, 311 (1963).

    CAS  Google Scholar 

  2. Vaughn, R. B., Brit. J. Exp. Path., 46, 71 (1965).

    Google Scholar 

  3. Filkins, J. P., and Di Luzio, N. R., J. Reticuloendothelial Soc., 3, 359 (1966).

    Google Scholar 

  4. Pisano, J. C., Filkins, J. P., and Di Luzio, N. R., Proc. Soc. Exp. Biol. Med., 128, 917 (1968).

    Article  CAS  PubMed  Google Scholar 

  5. Saba, T. M., and Di Luzio, N. R., J. Reticuloendothelial Soc., 4, 436 (1967).

    Google Scholar 

  6. Pisano, J. C., Patterson, J. T., and Di Luzio, N. R., Science, 162, 565 (1968).

    Article  ADS  CAS  PubMed  Google Scholar 

  7. Saba, T. M., and Di Luzio, N. R., Amer. J. Physiol., 216, 197 (1969).

    CAS  PubMed  Google Scholar 

  8. Pisano, J. C., and Di Luzio, N. R., J. Reticuloendothelial Soc. (in the press).

  9. Wooles, W. R., and Di Luzio, N. R., Science, 142, 1078 (1969).

    Article  ADS  Google Scholar 

  10. Sabet, T., Newlin, C., and Friedman, H., Proc. Soc. Exp. Biol. Med., 128, 274 (1968).

    Article  CAS  PubMed  Google Scholar 

  11. Sabet, T., Newlin, C., and Friedman, H., Immunology, 16, 433 (1968).

    Google Scholar 

  12. Goble, F. C., and Singer, I., Ann. NY Acad. Sci., 88, 149 (1960).

    Article  ADS  CAS  PubMed  Google Scholar 

  13. Hektoen, L., J. Infect. Dis., 5, 249 (1908).

    Article  CAS  Google Scholar 

  14. Prehn, R. T., and Main, J. M., J. Nat. Cancer Inst., 18, 769 (1957).

    CAS  PubMed  Google Scholar 

  15. Stern, K., J. Lab. Clin. Med., 26, 809 (1940).

    Google Scholar 

  16. Broch, G. J., Perille, P. E., and Finch, S. C., Blood, 26, 489 (1965).

    Google Scholar 

  17. Donovan, A. J., Amer. J. Surg., 114, 230 (1967).

    Article  Google Scholar 

  18. Salky, N. K., Di Luzio, N. R., Levin, A. G., and Goldsmith, H. S., J. Lab. Clin. Med., 70, 393 (1967).

    CAS  PubMed  Google Scholar 

  19. Saba, T. M., Filkins, J. P., and Di Luzio, N. R., J. Reticuloendothelial Soc., 3, 398 (1966).

    CAS  Google Scholar 

  20. Salky, N. K., Di Luzio, N. R., Pool, D. B. P., and Sutherland, A. J., J. Amer. Med. Assoc., 187, 744 (1964).

    Article  CAS  Google Scholar 

  21. Salky, N. K., Mills, D., and Di Luzio, N. R., J. Lab. Clin. Med., 66, 952 (1965).

    CAS  PubMed  Google Scholar 

  22. Bennett, B., and Boyse, E. A., Transplantation, 2, 183 (1964).

    Article  CAS  PubMed  Google Scholar 

  23. Di Luzio, N. R., Fed. Proc., 24, 614 (1965).

    Google Scholar 

  24. Mathe, G., Amiel, J. L., Schwarzenbert, L., Schneider, M., Catten, A., Schlumber, J. R., Hogart, M., and De Vassel, F., Rev. Fr. Etud. Clin. Biol., 13, 454 (1968); Lancet, i, 697 (1969).

    CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Physiology, Tulane University School of Medicine, New Orleans, Louisiana, 70112

    J. C. PISANO, N. R. DI LUZIO & N. K. SALKY

  2. Departments of Physiology and Biophysics and Medicine, University of Tennessee Medical Units, Memphis, Tennessee, 38103

    J. C. PISANO, N. R. DI LUZIO & N. K. SALKY

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  1. J. C. PISANO
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  2. N. R. DI LUZIO
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  3. N. K. SALKY
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PISANO, J., DI LUZIO, N. & SALKY, N. Inability of Plasma from Patients with Neoplasia to support Macrophage Recognition of Foreignness. Nature 226, 1049–1050 (1970). https://doi.org/10.1038/2261049a0

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  • DOI: https://doi.org/10.1038/2261049a0

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