Abstract
NON-RANDOM damage to the chromosomes of human embryo kidney (HEK) cells by adenovirus type 12 (in vitro) has been reported by Zur Hausen1. We have obtained similar results with adenovirus type 12 in fibroblasts grown from human embryo lung (HEL) and from skin biopsy samples, as well as in the epithelial HEK cells.
Similar content being viewed by others
References
Zur Hausen, H., J. Virol., 1, 1174 (1967).
Hamm, R. G., Exp. Cell Res., 29, 515 (1963).
Russell, W. C., Valentine, R. C., and Pereira, H. G., J. Gen. Virol., 1, 509 (1967).
Levan, A., and Nicholls, W. W., Hereditas, 51, 378 (1964).
Edwards, J. H., Harnden, D. G., Cameron, A. H., Crosse, V. M., and Wolff, O. H., Lancet, i, 787 (1960).
Patau, K., Therman, E., Smith, D. W., and DeMars, R. I., Chromosoma, 12, 280 (1961).
Yunis, J. J., Hook, E. B., and Mayer, M., Lancet, ii, 286 (1964).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
MCDOUGALL, J. Effects of Adenoviruses on the Chromosomes of Normal Human Cells and Cells Trisomic for an E Chromosome. Nature 225, 456–458 (1970). https://doi.org/10.1038/225456a0
Received:
Issue Date:
DOI: https://doi.org/10.1038/225456a0
- Springer Nature Limited
This article is cited by
-
Establishment of a preadipocyte cell line from the epididymal fat pad of the lean C57 BL/6J mouse—Long term effects of insulin and triiodothyronine on adipose conversion
In Vitro (1983)
-
Oncogenic adenovirus as mutagen for Chinese hamster cells in vitro
Somatic Cell Genetics (1982)
-
Establishment of a variant cell clone growing at 41° C from embryonic rat and tupaia (tree shrew) fibroblast cells
In Vitro (1978)
-
Malignant transformation of rat embryo fibroblasts by herpes simplex virus types 1 and 2 at suboptimal temperature
Nature (1977)
-
Susceptibility of xeroderma pigmentosum cells to chromosome breakage by adenovirus type 12
Nature (1974)