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Metabolism of Δ1(6)-Tetrahydro-cannabinol, an Active Marihuana Constituent

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Abstract

A METHOD for preparing specifically tritiated (—)-Δ1(6)-tetrahydrocannabinol (I) was recently developed in our laboratories1. We would now like to report some of the results we have obtained in studying the metabolic fate of this material in the rabbit. Several publications dealing with the metabolism of cannabinoids have appeared2,3 in which other species were used, but none of the metabolites was identified. Moreover, in some cases the methods used to obtain the labelled cannabinoids would not yield radiochemically pure substances.

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References

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Authors and Affiliations

  1. Worcester Foundation for Experimental Biology, Shrewsbury, Massachusetts, 01545

    SUMNER H. BURSTEIN, FRANCO MENEZES & ETHEL WILLIAMSON

  2. Laboratory of Natural Products, School of Pharmacy, Hebrew University, Jerusalem

    RAPHAEL MECHOULAM

Authors
  1. SUMNER H. BURSTEIN
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  2. FRANCO MENEZES
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  3. ETHEL WILLIAMSON
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  4. RAPHAEL MECHOULAM
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BURSTEIN, S., MENEZES, F., WILLIAMSON, E. et al. Metabolism of Δ1(6)-Tetrahydro-cannabinol, an Active Marihuana Constituent. Nature 225, 87–88 (1970). https://doi.org/10.1038/225087a0

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  • DOI: https://doi.org/10.1038/225087a0

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