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Detoxification of Diazinon by Subcellular Fractions of Diazinon-resistant and Susceptible Houseflies

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Abstract

HOUSEFLIES metabolize dialkyl phosphorothionate insecticides, such as diazinon and parathion, to the corresponding dialkyl phosphorothioic acids1,2. This reaction is thought to be controlled by gene a, on chromosome II (ref. 3), associated with low aliesterase activity4. The cleavage mechanism is reported to be in the microsomes2,5,6. I have found three detoxification mechanisms in subcellular fractions of six strains (Table 1) of housefly and related these to the genetics of diazinon-resistance7,8 of the flies.

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References

  1. Matsumura, F., and Hogendijk, C. J., J. Agric. Food Chem., 12, 447 (1964).

    Article  CAS  Google Scholar 

  2. Nakatsugawa, T., Tolman, N. M., and Dahm, P. A., J. Econ. Ent., 62, 408 (1969).

    Article  CAS  Google Scholar 

  3. Wagoner, D. E., Genetics (Princeton), 57, 729 (1967).

    CAS  Google Scholar 

  4. Oppenoorth, F. J., Ent. Exp. Appl., 2, 304 (1959).

    Article  CAS  Google Scholar 

  5. Nakatsugawa, T., and Dahm, P. A., Biochem. Pharmacol., 17, 1577 (1968).

    Article  Google Scholar 

  6. Fukami, J., and Shishido, T., J. Econ. Ent., 59, 1338 (1966).

    Article  CAS  Google Scholar 

  7. Sawicki, R. M., and Farnham, A. W., Bull. Ent. Res. (in the press).

  8. Sawicki, R. M., and Farnham, A. W., Ent. Exp. Appl., 10, 363 (1967).

    Article  Google Scholar 

  9. Gwiazda, M., and Lord, K. A., Ann. Appl. Biol., 59, 221 (1967).

    Article  CAS  Google Scholar 

  10. Hollingworth, R. M., Metcalf, R. L., and Fukuto, T. R., J. Agric. Fd. Chem., 15, 242 (1967).

    Article  CAS  Google Scholar 

  11. ElBasheir, S., and Oppenoorth, F. J., Nature, 223, 210 (1969).

    Article  ADS  CAS  Google Scholar 

  12. Oppenoorth, F. J., and van Asperen, K., Ent. Exp. Appl., 4, 311 (1961).

    Article  CAS  Google Scholar 

  13. Bell, J. D., Bull. Ent. Res., 58, 137 (1968).

    Article  Google Scholar 

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  1. Rothamsted Experimental Station, Harpenden, Hertfordshire

    J. B. LEWIS

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  1. J. B. LEWIS
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LEWIS, J. Detoxification of Diazinon by Subcellular Fractions of Diazinon-resistant and Susceptible Houseflies. Nature 224, 917–918 (1969). https://doi.org/10.1038/224917a0

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  • DOI: https://doi.org/10.1038/224917a0

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