Abstract
A COMMON drawback associated with the use of antineoplastic and immunosuppressive drugs is an increased susceptibility to infection1–4. This can be attributed, at least in part, to leucopenia5,6, hypogammaglobulinaemia7 and impairments of the normal processes of phagocytosis8 and the primary antibody response9–11. It was recently demonstrated that the antineoplastic agent cyclophosphamide depresses the production of interferon12 and causes higher peak titres of EMC virus in the mouse13, thus producing a striking increase in mortality. We now report that treatment of rats with Cyclophosphamide produces a rapidly increasing bacteriaemia together with significant bacterial proliferation within various organs following experimental infection with Staphylococcus aureus.
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SHARBAUGH, R., GROGAN, J. Effect of Cyclophosphamide on Experimental Staphylococcus Infection in the Rat. Nature 224, 809–810 (1969). https://doi.org/10.1038/224809a0
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DOI: https://doi.org/10.1038/224809a0
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