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Release of 3H-γ-Aminobutyric Acid from the Brain during Synaptic Inhibition

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Abstract

γ-Aminobutyric acid is shown to be specifically released from the brain during synaptic inhibition, which suggests that it may be an important central inhibitory transmitter.

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References

  1. Roberts, E., and Frankel, S., Fed. Proc., 9, 219 (1950).

    Google Scholar 

  2. Otsuka, M., Iversen, L. L., Hall, Z. W., and Kravitz, E. A., Proc. US Nat. Acad. Sci., 56, 1110 (1966).

    Article  ADS  CAS  Google Scholar 

  3. Iwama, K., and Jasper, H. H., J. Physiol., 138, 365 (1957).

    Article  CAS  Google Scholar 

  4. Krnjević, K., Randić, M., and Straughan, D. W., J. Physiol., 184, 16 (1966).

    Article  Google Scholar 

  5. Krnjević, K., and Schwartz, S., Exp. Brain Res., 3, 320 (1967).

    Article  Google Scholar 

  6. Obata, K., and Takeda, K., J. Neurochem., 16, 1043 (1969).

    Article  CAS  Google Scholar 

  7. Florey, E., and MacLennan, H., J. Physiol., 129, 384 (1955).

    Article  CAS  Google Scholar 

  8. Jasper, H. H., Khan, R. T., and Elliott, K. A. C., Science, 147, 1448 (1965).

    Article  ADS  CAS  Google Scholar 

  9. Crowshaw, K., Jessup, S. J., and Ramwell, P. W., Biochem. J., 103, 79 (1967).

    Article  CAS  Google Scholar 

  10. Srinivasan, V., Neal, M. J., and Mitchell, J. F., J. Neurochem., 16, 1235 (1969).

    Article  CAS  Google Scholar 

  11. Neal, M. J., and Iversen, L. L., J. Neurochem., 16, 1245 (1969).

    Article  CAS  Google Scholar 

  12. Mitchell, J. F., J. Physiol., 165, 98 (1963).

    Article  CAS  Google Scholar 

  13. Moore, S., and Stein, W. H., J. Biol. Chem., 176, 367 (1948).

    CAS  PubMed  Google Scholar 

  14. Iversen, L. L., and Kravitz, E. A., J. Neurochem., 15, 609 (1968).

    Article  CAS  Google Scholar 

  15. Mitchell, J. F., and Srinivasan, V., J. Physiol., 204, 23P (1969).

    Google Scholar 

  16. Burgen, A. S. V., and Spero, L., Brit. J. Pharmacol. Chemother., 34, 99 (1968).

    Article  CAS  Google Scholar 

  17. Li, Ch.-L., Oritz-Golvin, A., Chou, S. N., and Howard, S. Y., J. Neurophysiol., 23, 592 (1960).

    Article  CAS  Google Scholar 

  18. Krnjević, K., and Phillis, J. W., J. Physiol., 165, 274 (1963).

    Article  Google Scholar 

  19. Iversen, L. L., and Neal, M. J., J. Neurochem., 15, 1141 (1968).

    Article  CAS  Google Scholar 

  20. Lovell, R. A., and Elliott, K. A. C., J. Neurochem., 10, 479 (1963).

    Article  CAS  Google Scholar 

  21. Tower, D. B., in Inhibition in the Nervous System and γ-Aminobutyric Acid (edit. by Roberts, E.) (Pergamon, London, 1960).

    Google Scholar 

  22. Roberts, E., in Structure and Function of Inhibitory Neuronal Mechanisms (edit. by von Euler, C., Skoglund, S., and Soderberg, U.) (Pergamon, London, 1968).

    Google Scholar 

  23. Hayashi, T., in Inhibition in the Nervous System and γ-Aminobutyric Acid (edit. by Roberts, E.) (Pergamon, London, 1960).

    Google Scholar 

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MITCHELL, J., SRINIVASAN, V. Release of 3H-γ-Aminobutyric Acid from the Brain during Synaptic Inhibition. Nature 224, 663–666 (1969). https://doi.org/10.1038/224663a0

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  • DOI: https://doi.org/10.1038/224663a0

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