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Excision of Thymine Dimers and Other Mismatched Sequences by DNA Polymerase of Escherichia coli

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Abstract

A nuclease function of DNA polymerase excises mismatched regions of DNA. Exercise of its multiple functions in vivo might enable this enzyme to participate in the excision and repair of DNA lesions, as well as in replication of DNA.

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Author notes

  1. REGIS B. KELLY

    Present address: Department of Neurobiology, Harvard Medical School, Boston, Massachusetts

  2. MAURICE R. ATKINSON: On leave from the School of Biological Sciences, Flinders University, Bedford Park, South Australia.

Authors and Affiliations

  1. Department of Biochemistry, Stanford University School of Medicine, Stanford, California

    REGIS B. KELLY, MAURICE R. ATKINSON, JOEL A. HUBERMAN & ARTHUR KORNBERG

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  1. REGIS B. KELLY
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  2. MAURICE R. ATKINSON
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  3. JOEL A. HUBERMAN
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  4. ARTHUR KORNBERG
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KELLY, R., ATKINSON, M., HUBERMAN, J. et al. Excision of Thymine Dimers and Other Mismatched Sequences by DNA Polymerase of Escherichia coli. Nature 224, 495–501 (1969). https://doi.org/10.1038/224495a0

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  • DOI: https://doi.org/10.1038/224495a0

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