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Mitochondrial Increase after Long-term Feeding of Morfamquat

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Abstract

MORFAMQUAT dichloride (MFQ) is a herbicide (Plant Protection Limited) which produces degeneration and necrosis of the proximal convoluted tubules in the kidney when administered to rats and dogs in acutely toxic doses. Ninety day feeding tests have, however, shown that low dietary concentrations (0.015 per cent) cause marked enlargement of certain cells in a circumscribed area of the kidney, remote from the proximal tubules and this preliminary report describes the histology, histo-chemistry and electron microscopy of these abnormal cells in rat kidneys.

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Authors and Affiliations

  1. Imperial Chemical Industries Limited, Industrial Hygiene Research Laboratories, Alderley Park, Macclesfield, Cheshire

    D. M. FERGUSON, J. E. ETHERTON & M. J. HAYES

Authors
  1. D. M. FERGUSON
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  2. J. E. ETHERTON
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  3. M. J. HAYES
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FERGUSON, D., ETHERTON, J. & HAYES, M. Mitochondrial Increase after Long-term Feeding of Morfamquat. Nature 224, 83–84 (1969). https://doi.org/10.1038/224083b0

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