Abstract
Rifampicin appears to inhibit the replication of poxvirus by blocking the synthesis of virus protein late in the growth cycle. The antibiotic inhibits the multiplication of trachoma agent in vitro, and in vivo; it has been used successfully to treat trachoma infection of a baboon's eye. The hydrazone side-chain of rifampicin appears to be essential for its anti-viral and anti-trachomal activity.
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References
Maggi, N., Pasqualucci, C. R., Ballotta, R., and Sensi, P., Chemotherapia, 11, 285 (1966).
Maggi, N., Pallanza, R., and Sensi, P., Antimicrobial Agents and Chemo-therapy, 765 (1965).
Becker, Y., and Zakay-Rones, Z., Nature, 222, 851 (1969).
Geiduschek, E. P., and Sklar, J., Nature, 221, 833 (1969).
Haselkorn, R., Vogel, M., and Brown, R. D., Nature, 221, 836 (1969).
Wehrli, W., Knüsel, F., Schmidt, K., and Staehelin, M., Proc. US Nat. Acad. Sci., 61, 667 (1968).
diMauro, E., Snyder, L., Marino, P., Lamberti, A., Coppo, A., and Tocchini-Valentini, G. P., Nature, 222, 533 (1969).
Kates, J. R., and McAuslan, B. R., Proc. US Nat. Acad. Sci., 58, 134 (1967).
Heller, E., Argaman, M., Levy, H., and Goldblum, N., Nature, 222, 273 (1969).
Subak-Sharpe, J. H., Timbury, M. C., and Williams, J. F., Nature, 222, 341 (1969).
Becker, Y., and Joklik, W. K., Proc. US Nat. Acad. Sci., 51, 577 (1964).
Oda, K., and Joklik, W. K., J. Mol. Biol., 27, 395 (1967).
Joklik, W. K., and Becker, Y., J. Mol. Biol., 10, 452 (1964).
Joklik, W. K., and Becker, Y., J. Mol. Biol., 13, 511 (1965).
Holowczak, J. A., and Joklik, W. K., Virology, 33, 717 (1967).
Penman, S., Scherrer, K., Becker, Y., and Darnell, J. E., Proc. US Nat, Acad. Sci., 49, 654 (1963).
Holowczak, J. A., and Joklik, W. K., Virology, 33, 726 (1967).
Wilcox, W. C., and Cohen, G. H., J. Virol., 1, 500 (1967).
Salzman, N. P., and Sebring, E. D., J. Virol., 1, 16 (1967).
Easterbrook, K. B., Virology, 17, 244 (1962).
Woodson, B., and Joklik, W. K., Proc. US Nat. Acad. Sci., 54, 946 (1965).
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BEN-ISHAI, Z., HELLER, E., GOLDBLUM, N. et al. Rifampicin Poxvirus and Trachoma Agent: Rifampicin and Poxvirus Replication. Nature 224, 29–32 (1969). https://doi.org/10.1038/224029a0
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DOI: https://doi.org/10.1038/224029a0
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