Skip to main content
SpringerLink
Log in

Cyclic AMP regulates Catabolite and Transient Repression in E. coli

  • Article
  • Published:

From Nature

View current issue Submit your manuscript

Abstract

Transient and catabolite repression of the synthesis of β-galactosidase in E. coli are related phenomena, the result of a decreased intracellular concentration of cyclic AMP. The lac operon promoter is the site of action of the cyclic AMP.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Perlman, R., and Pastan, I., Biochem. Biophys. Res. Commun., 30, 656 (1968).

    Article  CAS  Google Scholar 

  2. Perlman, R. L., and Pastan, I., J. Biol. Chem., 243, 5420 (1968).

    CAS  PubMed  Google Scholar 

  3. Pastan, I., and Perlman, R. L., Proc. US Nat. Acad. Sci., 61, 1336 (1968).

    Article  ADS  CAS  Google Scholar 

  4. Goldenbaum, P. E., and Dobrogosz, W. J., Biochem. Biophys. Res. Commun., 33, 828 (1968).

    Article  CAS  Google Scholar 

  5. Ullmann, A., and Monod, J., FEBS Letters, 2, 57 (1968).

    Article  CAS  Google Scholar 

  6. Magasanik, B., Cold Spring Harbor Symp. Quant. Biol., 26, 193 (1961).

    Article  Google Scholar 

  7. Boezi, J. A., and Cowie, D. B., Biophys. J., 1, 639 (1961).

    Article  ADS  CAS  Google Scholar 

  8. Tyler, B., Loomis, jun., W. F., and Magasanik, B., J. Bacteriol., 94, 2001 (1967).

    CAS  PubMed  PubMed Central  Google Scholar 

  9. Cohn, M., and Horibata, K., J. Bacteriol., 78, 601 (1959).

    CAS  PubMed  PubMed Central  Google Scholar 

  10. Makman, R. S., and Sutherland, E. W., J. Biol. Chem., 240, 1309 (1965).

    CAS  PubMed  Google Scholar 

  11. Hsie, A. W., and Rickenberg, H. W., Biochem. Biophys. Res. Commun., 29, 303 (1967).

    Article  CAS  Google Scholar 

  12. Silverstone, A. E., Magasanik, B., Reznikoff, W. S., Miller, J. H., and Beckwith, J. R., Nature, 221, 1012 (1969).

    Article  ADS  CAS  Google Scholar 

  13. Miller, J. H., Ippen, K., Scaife, J. G., and Beckwith, J. R., J. Mol. Biol., 38, 413 (1968).

    Article  CAS  Google Scholar 

  14. Loomis, jun., W. F., and Magasanik, B., Biochem. Biophys. Res. Commun., 20, 230 (1965).

    Article  Google Scholar 

  15. Rickenberg, H. V., Hsie, A. W., and Janacek, J., Biochem. Biophys. Res. Commun., 31, 603 (1968).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Clinical Endocrinology Branch, National Institute of Arthritis and Metabolic Diseases, National institutes of Health, Bethesda, Maryland, 20014

    ROBERT L. PERLMAN, BENOIT DE CROMBRUGGHE & IRA PASTAN

Authors
  1. ROBERT L. PERLMAN
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. BENOIT DE CROMBRUGGHE
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. IRA PASTAN
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

PERLMAN, R., DE CROMBRUGGHE, B. & PASTAN, I. Cyclic AMP regulates Catabolite and Transient Repression in E. coli. Nature 223, 810–812 (1969). https://doi.org/10.1038/223810a0

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1038/223810a0

  • Springer Nature Limited

This article is cited by

Search

Navigation