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RNA-DNA Hybrids at the Cytological Level

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Abstract

Radioactive RNA introduced into “target” cells can be induced to form hybrids with nuclear DNA. The location of these hybrids can be detected by autoradiography.

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References

  1. Dubnau, D., Smith, I., and Marmur, J., Proc. US Nat. Acad. Sci., 54, 724 (1965); Smith, I., Dubnau, D., Morell, P., and Marmur, J., J. Mol. Biol., 33, 123 (1968); Oishi, M., Oishi, A., and Sueoka, N., Proc. US Nat. Acad. Sci., 55, 1095 (1966).

    Article  ADS  CAS  Google Scholar 

  2. Geiduschek, E. P., Snyder, L., Colvill, A. J. E., and Sarnat, M. J., Mol. Biol., 19, 541 (1966); Taylor, K., Hradecna, Z., and Szybalski, W., Proc. US Nat. Acad. Sci., 57, 1618 (1967); Cohen, S. N., and Hurwitz, J., Proc. US Nat. Acad. Sci., 57, 1759 (1967).

    Article  CAS  Google Scholar 

  3. Spiegelman, S., and Yankofsky, S. A., in Evolving Genes and Proteins (edit. by Bryson, V., and Vogel, H. J.), 537 (Academic Press, New York, 1965).

    Book  Google Scholar 

  4. Birnstiel, M., Wallace, H., Sirlin, J., and Fischberg, M., Nat. Cancer Inst. Monog., 23, 431 (1966).

    CAS  Google Scholar 

  5. Hennig, W., J. Mol. Biol., 38, 227 (1968).

    Article  CAS  Google Scholar 

  6. Britten, R. J., and Kohne, D. E., Carnegie Institution Yearbook, 78 (1966/7); Wetmur, J. G., and Davidson, N., J. Mol. Biol., 31, 349 (1968).

    Google Scholar 

  7. Scherrer, K., and Darnell, J. E., Biochem. Biophys. Res. Commun., 7, 486 (1962).

    Article  CAS  Google Scholar 

  8. Loening, U. E., Biochem. J., 102, 251 (1967).

    Article  CAS  Google Scholar 

  9. Birnstiel, M., Speirs, J., Purdom, I., Jones, K., and Loening, U. E., Nature, 219, 454 (1968).

    Article  ADS  CAS  Google Scholar 

  10. Yankofsky, S. A., and Spiegelman, S., Proc. US Nat. Acad. Sci., 51, 1197 (1964).

    Article  Google Scholar 

  11. Flamm, W. G., Bond, H. E., and Burr, H. E. Biochem. Biophys. Acta, 129, 310 (1966).

    CAS  Google Scholar 

  12. Nygaard, A. P., and Hall, B. D., Biochem. Biophys. Res. Commun., 12, 98 (1963).

    Article  CAS  Google Scholar 

  13. Perry, R. P., in Methods in Cell Physiology (edit. by Prescott, D. M.), 1, 324 (Academic Press, New York, 1964).

    Google Scholar 

  14. Huang, R. C., and Bonner, J., Proc. US Nat. Acad. Sci., 48, 1216 (1962).

    Article  ADS  CAS  Google Scholar 

  15. Murray, K., Ann. Rev. Biochem., 34, 209 (1965).

    Article  CAS  Google Scholar 

  16. Frenster, J. H., Nature, 206, 680 (1965).

    Article  ADS  CAS  Google Scholar 

  17. Bonner, J., Dahmus, M. E., Fambrough, D., Huang, R. C., Marushige, K., and Tuan, D. Y. H., Science, 159, 47 (1968).

    Article  ADS  CAS  Google Scholar 

  18. Paul, J., and Gilmour, R. S., J. Mol. Biol., 34, 305 (1968).

    Article  CAS  Google Scholar 

  19. Macgregor, H. C., J. Cell. Sci., 3, 437 (1968).

    Google Scholar 

  20. Gall, J. G., Genetics (in the press).

  21. Gall, J. G., and Pardue, M. L., Proc. US Nat. Acad. Sci. (in the press).

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Authors and Affiliations

  1. MRC Epigenetics Research Group, Institute of Animal Genetics, University of Edinburgh,

    H. A. JOHN, M. L. BIRNSTIEL & K. W. JONES

Authors
  1. H. A. JOHN
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  2. M. L. BIRNSTIEL
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  3. K. W. JONES
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JOHN, H., BIRNSTIEL, M. & JONES, K. RNA-DNA Hybrids at the Cytological Level. Nature 223, 582–587 (1969). https://doi.org/10.1038/223582a0

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  • DOI: https://doi.org/10.1038/223582a0

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