Skip to main content
SpringerLink
Log in

Effects of Aminooxyacetic Acid on Cochlear Potentials and the Preyer Reflex

  • Letter
  • Published:

From Nature

View current issue Submit your manuscript

Abstract

AMINOOXYACETIC acid (AOAA) protects against convulsions induced by chemical agents1–3, electroshock1 and sound4. This activity has been associated with a substantial increase in brain γ-aminobutyric acid (GABA) through an inhibition of GABA aminotransferase2.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Kuriyama, K., Roberts, E., and Rubinstein, M. K., Biochem. Pharmacol., 15, 221 (1966).

    Article  CAS  Google Scholar 

  2. Roa, P. D., Tews, J. K., and Stone, W. E., Biochem. Pharmacol., 13, 477 (1964).

    Article  CAS  Google Scholar 

  3. Davanzo, J. P., Greig, M. E., and Cronin, M. A., Amer. J. Physiol., 201, 833 (1961).

    PubMed  CAS  Google Scholar 

  4. Schlesinger, K., and Boggan, W., Life Sci., 7, 437 (1968).

    Article  CAS  Google Scholar 

  5. Bobbin, R. P., and Guth, P. S., Fed. Proc., 28, 2885 (1969).

    Google Scholar 

  6. Preyer, W., Die Seele des Kindes (Grieben-Verlag, Leipzig, Germany, 1882).

    Google Scholar 

  7. Gerstner, H., Pflueger Arch. Ges. Physiol., 246, 265 (1942).

    Article  Google Scholar 

  8. Anderson, H., and Wedenberg, E., Acta Otolaryngol., 60, 375 (1965).

    Article  Google Scholar 

  9. Totsuka, G., Nakamura, K., and Kirikae, I., Ann. Otol. Rhinol. Laryngol., 63, 938 (1954).

    Article  Google Scholar 

  10. Tanaka, Y., and Katsuki, Y., J. Neurophysiol., 29, 94 (1966).

    Article  CAS  Google Scholar 

  11. Desmedt, J. E., and Monaco, P., Proc. First Intern. Pharmacol. Meet., 8, 183 (Pergamon Press, Oxford, 1962).

    CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Departments of Pharmacology and Otolaryngology, Tulane University, New Orleans, Louisiana

    R. P. BOBBIN, G. GONZALEZ & P. S. GUTH

Authors
  1. R. P. BOBBIN
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. G. GONZALEZ
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. P. S. GUTH
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

BOBBIN, R., GONZALEZ, G. & GUTH, P. Effects of Aminooxyacetic Acid on Cochlear Potentials and the Preyer Reflex. Nature 223, 70–71 (1969). https://doi.org/10.1038/223070a0

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1038/223070a0

  • Springer Nature Limited

This article is cited by

Search

Navigation