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Passive Antibody may simultaneously suppress and stimulate Antibody Formation against Different Portions of a Protein Molecule

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Abstract

IMMUNE suppression is the specifically induced suppression of antibody synthesis by antibodies1–3 (a comprehensive review can be found in ref. 4). Suppression has been demonstrated with various immunogens, including protein molecules1,5, bacterial flagella6, bacteriophage7, red blood cells2,3,8 and other cellular antigens9, and haptenic groups conjugated to protein10. The observed specificity of the phenomenon1,8–10 implies that the passively administered antibodies must somehow combine with antigen.

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Authors and Affiliations

  1. Department of Pathology, New York University School of Medicine,

    CAROLYN S. PINCUS & VICTOR NUSSENZWEIG

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  1. CAROLYN S. PINCUS
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  2. VICTOR NUSSENZWEIG
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PINCUS, C., NUSSENZWEIG, V. Passive Antibody may simultaneously suppress and stimulate Antibody Formation against Different Portions of a Protein Molecule. Nature 222, 594–596 (1969). https://doi.org/10.1038/222594a0

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  • DOI: https://doi.org/10.1038/222594a0

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