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Red Cell ATP and Malaria Infection

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Abstract

SEVERAL genetic polymorphisms involving haemoglobin and glucose-6-phosphate dehydrogenase are thought to provide a measure of protection against human malarias1. These are all single gene traits, but quantitative variables within the human red cell may also be of importance. Thus Brewer and Powell2 have demonstrated a strong positive correlation between the level of erythrocyte ATP and the rapidity with which a parasitaemia of 1,000 per mm3 is reached during experimental infections of humans with falciparum malaria. The higher the level of red cell ATP, the more rapidly parasitaemia develops, at least in the early stages of infection. This study was designed to investigate the relationship between red cell ATP level and the development of parasitaemia in a different species infected with a different form of malaria.

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References

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Authors and Affiliations

  1. Departments of Anthropology, Human Genetics and Medicine (Simpson Memorial Institute), University of Michigan, Ann Arbor

    JOHN W. EATON & GEORGE J. BREWER

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  1. JOHN W. EATON
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  2. GEORGE J. BREWER
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EATON, J., BREWER, G. Red Cell ATP and Malaria Infection. Nature 222, 389–390 (1969). https://doi.org/10.1038/222389a0

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