Abstract
STRUCTURAL parameters of different groups of non-steroidal ariti-inflammatory agents (pyrazolidinediones1, fenamates2, indoles3, oxazoles4 and thiazoles4) have certain similarities which include the presence of a relatively non-basic nitrogen, an acidic (carboxylic or enolic) function and an aromatic moiety. We report here the synthesis and biological properties of a new and potent series of anti-inflammatory agents which manifest similar structural features.
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KADIN, S., WISEMAN, E. Dioxoisoquinoline-4-carboxanilides—A New Class of Non-steroidal Anti-inflammatory Agents. Nature 222, 275–276 (1969). https://doi.org/10.1038/222275a0
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DOI: https://doi.org/10.1038/222275a0
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