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Renal Lesions in Young Adoptively Immunized NZB/BI Mice

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Abstract

THE “autoimmune” NZB/Bl strain of mice is characterized by the spontaneous occurrence of haemolytic anaemia1 and red cell autoantibodies2–4. Renal lesions are also present, and immunofluorescent techniques have shown deposits of gamma globulin in the glomerular tuft5,6, suggesting a primary autoimmune renal disorder6. We have used adoptive immunization to investigate renal lesions in NZB/Bl mice in an attempt to relate the lesions to the occurrence of red cell autoantibodies.

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References

  1. Bielschowsky, Marianne, Helyer, B. J., and Howie, J. B., Proc. Univ. Otago Med. Sch., 37, 9 (1959).

    Google Scholar 

  2. Holmes, M. C., Gorrie, J., and Burnet, F. M., Lancet, ii, 639 (1961).

  3. Long, Gwenneth, Holmes, Margaret C., and Burnet, F. M., Austral. J. Exp. Biol. Med. Sci., 41, 315 (1963).

    Article  CAS  Google Scholar 

  4. Holborow, E. J., Barnes, R. D., and Tuffrey, Maureen A., Nature, 207, 601

  5. Aarons, I., Nature, 203, 1080 (1964).

    Article  ADS  CAS  Google Scholar 

  6. Mellors, R. C., J. Exp. Med., 123, 1025 (1966).

    Article  CAS  Google Scholar 

  7. Barnes, R. D., Tuffrey, Maureen, and Holliday, Jean, J. Med. Genet., 5, 129 (1968).

    Article  CAS  Google Scholar 

  8. Barnes, R. D., and Tuffrey, Maureen, Nature, 209, 1095 (1966).

    Article  ADS  CAS  Google Scholar 

  9. Sainte-Marie, G., J. Histochem. Cytochem., 10, 250 (1961).

    Article  Google Scholar 

  10. Johnson, G. D., Nature, 191, 70 (1961).

    Article  ADS  CAS  Google Scholar 

  11. Mellors, R. C., and Huang, C. Y., J. Exp. Med., 123, 1025 (1966).

    Article  CAS  Google Scholar 

  12. Lambert, P. H., and Dixon, F. S., J. Exp. Med., 127, 507 (1968).

    Article  CAS  Google Scholar 

  13. Mellors, R. C., and Huang, C. Y., J. Exp. Med., 124, 1031 (1966).

    Article  CAS  Google Scholar 

  14. East, J., Prosser, P. R., Holborow, E. S., and Jaquet, H., Lancet, i, 755 (1967).

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Authors and Affiliations

  1. Departments of Haematology and Morbid Anatomy, Institute of Child Health, Guilford Street, London

    R. D. BARNES, C. L. BERRY & JEAN HOLLIDAY

Authors
  1. R. D. BARNES
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  2. C. L. BERRY
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  3. JEAN HOLLIDAY
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BARNES, R., BERRY, C. & HOLLIDAY, J. Renal Lesions in Young Adoptively Immunized NZB/BI Mice. Nature 222, 188–190 (1969). https://doi.org/10.1038/222188a0

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  • DOI: https://doi.org/10.1038/222188a0

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