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Inhibition of Bone Growth in vitro by Endotoxin: Histamine Effect

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Abstract

BECAUSE bacteria are found in close proximity to soft tissue and bone in the oral cavity, it seems logical that bacterial endotoxin could affect the metabolism of bone and contribute to the bone loss seen in periodontal disease. We investigated the effects of bacterial endotoxins on rapidly growing bone in an organ culture system. Also, because there is evidence that histamine affects the activity of endotoxin1–3, we cultured bones in an environment containing both endotoxin and histamine, and found that synthesis of structural protein was inhibited without affecting cell turnover.

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Authors and Affiliations

  1. Department of Orthodontics, College of Dentistry, University of Kentucky, Lexington, Kentucky

    LOUIS A. NORTON, WILLIAM R. PROFFIT & RONALD R. MOORE

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  1. LOUIS A. NORTON
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  2. WILLIAM R. PROFFIT
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  3. RONALD R. MOORE
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NORTON, L., PROFFIT, W. & MOORE, R. Inhibition of Bone Growth in vitro by Endotoxin: Histamine Effect. Nature 221, 469–471 (1969). https://doi.org/10.1038/221469a0

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  • DOI: https://doi.org/10.1038/221469a0

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