Abstract
There is evidence that certain polypeptide hormones are synthesized and stored as protein precursors with a primary structure which includes a high proportion of carboxyl and carboxamido side chains, and a secondary structure which is predominantly that of a random coil polymer.
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References
Pearse, A. G. E., Nature, 211 598 (1966).
Pearse, A. G. E., Vet. Rec., 79, 597 (1966).
Pearse, A. G. E., Proc. Roy. Soc., B, 164, 478 (1966).
Pearse, A. G. E., Proc. Roy. Soc., B, 170, 71 (1968).
Solcia, E., and Sampietro, R., Riv. Istochim., 11, 265 (1965).
Mizock, B. J., and Ferguson, D. J., Surg. Forum, 17, 299 (1966).
Carvalheira, A. F., Welsch, U., and Pearse, A. G. E., Histochemie, 14, 33 (1968).
McGuigan, J. E., Gastroenterology, 55, 315 (1968).
Feyrter, F., Ver. Deutsch. Ges. Pathol., 33, 155 (1949).
Smith, A. D., and Winkler, H., Biochem. J., 103, 483 (1967).
Blaschko, H., Hagen, J. M., and Hagen, P., J. Physiol., 139, 316 (1957).
Manocchio, I., Arch. Vet. Ital., 15, 3 (1964).
Solcia, E., and Sampietro, R., Riv. Istochim. Norm. Patol., 12, 122 (1966).
Solcia, E., Vassallo, G., and Capella, C., Stain Tech., 43, 257 (1968).
Stoward, P. J., and Burns, J., Histochemie, 10, 230 (1967).
Barrnett, R. J., and Seligman, A. M., J. Biochem. Biophys. Cytol., 4, 169 (1958).
Kopple, K. D., Peptides and Amino Acids, 82 (Benjamin, New York, 1966).
Neher, R., Riniker, B., Zuber, H., Rittel, W., and Kahnt, F. W., Helvet. Chim. Acta, 51, 917 (1968).
Potts, jun., J. T., Niall, H. D., Keutmann, H. T., Brewer, jun., H. B., and Deftos, L. J., Proc. US Nat. Acad. Sci., 59, 1321 (1968).
Anderson, J. C., Barton, M. A., Gregory, R. A., Hardy, P. M., Kenner, G. W., MacLeod, J. K., Preston, J., Sheppard, R. C., and Morley, J. S., Nature, 204, 933 (1964).
Dayhoff, M. O., and Eck, R. V., Atlas of Protein Sequence and Structure (Nat. Biomed. Res. Foundation, 1967–68).
Chibnall, A. C., Haselbach, C., Mangan, J. L., and Rees, M. W., Biochem. J., 68, 122 (1958).
Hill, R. L., Advanc. Prot. Chem., 20, 37 (1965).
Iizuka, E., and Yang, J. T., Biochemistry, 4, 1249 (1965).
Preston, B. N., Davies, M., and Ogston, A. G., Biochem. J., 96, 449 (1965).
Francois, C. J., and Glimcher, M. J., Biochim Biophys. Acta, 133, 91 (1967).
Gouinlock, E. V., Flory, P. J., and Scheraga, H. A., J. Polymer Sci., 16, 383 (1955).
Szent-Györgyi, A., and Cohen, C., Science, 126, 697 (1957).
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PEARSE, A. Random Coil Conformation of Polypeptide Hormone Precursor Protein in Endocrine Cells. Nature 221, 1210–1211 (1969). https://doi.org/10.1038/2211210a0
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