Abstract
A mutant line of the P388F lymphoma has been used as recipient for labelled DNA. A distinct peak of DNA resulted which was well separated from those given by donor and recipient DNA. This suggests true integration of DNA into the recipient genome.
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Avery, O. T., MacLeod, C. M., and McCarty, M., J. Exp. Med., 79, 137 (1944).
Kraus, L. M., Nature, 192, 1055 (1961).
Szybalska, E. H., and Szybalski, W., Proc. US Nat. Acad. Sci., 48, 2926 (1962).
Ledoux, L., Prog. Nucleic Acid Res. and Mol. Biol., 4, 231 (1965).
Sirotnak, F. M., and Hutchinson, D. J., Biochim. Biophys. Acta, 36, 246 (1959).
Ricke, W. O., J. Cell. Biol., 13, 205 (1962).
Grosse, Ch., LePecq, J. B., De France, P., and Paoletti, C., Cancer Res., 25, 877 (1965).
Bendich, A., Wilczok, T., and Borenfreund, E., Science, 148, 374 (1965).
Ledoux, L., Gerber, G. R., Charles, P., Remy, J., and Remy-Defraigue, J., Experientia, 23, 16 (1967).
Ledoux, L., and Huart, R., Biochim. Biophys. Acta, 134, 209 (1967).
Ledoux, L., Charles, P., and Srögel, M., Nature, 214, 1241 (1967).
Robins, A. B., and Taylor, D. M., Nature, 214, 1228 (1968).
Ayad, S. R., and Barker, G. R., Biochem. J. (in the press).
Bodmer, W. F., and Ganesan, A. T., Genetics, 50, 717 (1964).
Levine, J. S., and Strauss, M., J. Bact., 89, 281, 288 (1965).
Fox, M. S., J. Gen. Physiol., 49, 183 (1966).
Kit, S., Dubbs, D. R., Piekarski, L. J., and Hsu, T. C., Exp. Cell Res., 31, 297 (1963).
Fox, M., and Gilbert, C. W., Intern. Radiat. Biol., 11, 339 (1966).
Fox, M., and Fox, B. W., Cancer Res., 27, 1805 (1967).
Nias, A. H. W., and Fox, M., Brit. J. Radiol., 41, 468 (1968).
Pasternak, C. A., Fischer, G. A., and Handschumacher, R. E., Cancer Res., 21, 110 (1961).
Fischer, G. A., and Sartorelli, A. S., Meth. Med. Res., 10, 247 (1964).
Sueoka, N., and Cheng, T., J. Mol. Biol., 4, 161 (1961).
Cleaver, J. E., Nature, 218, 652 (1968).
Kay, E. R. M., Trans. NY Acad. Sci., 28, 726 (1966).
Painter, R. B., and Cleaver, J. E., Nature, 216, 369 (1967).
Hakala, M. T., J. Biol. Chem., 234, 3072 (1963).
Kajiwara, K., and Mueller, G. C., Biochim. Biophys. Acta, 91, 486 (1964).
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AYAD, S., FOX, M. DNA Uptake by a Mutant Strain of Lymphoma Cells. Nature 220, 35–38 (1968). https://doi.org/10.1038/220035a0
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DOI: https://doi.org/10.1038/220035a0
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