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In vitro Culture of an Organ containing Mixed Epithelial and Connective Tissues on a Chemically Defined Medium

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Abstract

EMBRYONIC mouse mandibles contain a variety of epithelial and connective tissue elements. These include the stratified squamous epithelia of skin and gingiva and the dental epithelia of the developing teeth, the connective tissues of skin, gingiva and the developing dental pulp, bone, dentine and cartilage. Nerve and muscle are also present. The in vitro culture of such an organ on a chemically defined medium would provide a system in which the effects of specific substances on different epithelia and connective tissues, and on the interactions occurring between these tissues, could be examined in controlled conditions.

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References

  1. Waymouth, C., J. Nat. Cancer Inst., 22, 1003 (1959).

    Article  CAS  Google Scholar 

  2. Kember, N. F., J. Bone Joint Surg., 42 B, 824 (1960).

    Article  Google Scholar 

  3. Tonna, E. A., and Cronkite, E. P., Nature, 190, 459 (1961).

    Article  ADS  CAS  Google Scholar 

  4. Weinmann, J. P., and Schour, I., Amer. J. Pathol, 21, 833 (1945).

    CAS  Google Scholar 

  5. Irving, J. T., and Handelman, C. S., in Mechanisms of Hard Tissue Destruction (edit. by Sognnaes, R. F.), 515 (Amer. Assoc. for the Advancement of Science, Washington, 1963).

    Google Scholar 

  6. Goldhaber, P., J. Dent. Res., 45, 491 (1966).

    Article  Google Scholar 

  7. Goldhaber, P., Amer. Med. Assoc. Arch. Pathol, 66, 635 (1958).

    CAS  Google Scholar 

  8. Goldhaber, P., in Mechanisms of Hard Tissue Destruction (edit. by Sognnaes, R. F.) (Amer. Assoc. for the Advancement of Science, Washington, No.,75, 1963).

    Google Scholar 

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Authors and Affiliations

  1. Department of Dental Science, Royal College of Surgeons of England,

    A. H. MELCHER

  2. Tissue and Organ Culture Unit, Imperial Cancer Research Fund, Lincoln's Inn Fields, London

    G. M. HODGES

Authors
  1. A. H. MELCHER
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  2. G. M. HODGES
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MELCHER, A., HODGES, G. In vitro Culture of an Organ containing Mixed Epithelial and Connective Tissues on a Chemically Defined Medium. Nature 219, 301–302 (1968). https://doi.org/10.1038/219301a0

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