Abstract
EXCITATION-CONTRACTION (E-C) coupling in skeletal muscle is a series of events leading from membrane depolarization to the production of tension1. One of the more important intermediary processes is a transient increase in the sarcoplasmic calcium concentration (calcium transient2) during the rising phase of tension. We have simultaneously recorded changes in membrane potential, calcium transient and tension during a single contraction of an isolated muscle fibre.
Similar content being viewed by others
References
Sandow, A., Pharm. Rev., 17, 265 (1965).
Ridgway, E. B., and Ashley, C. C., Biochem. Biophys. Res. Commun., 29, 229 (1967).
Hoyle, G., and Smyth, T., Comp. Biochem. Physiol., 10, 291 (1963).
Shimomura, O., Johnson, F., and Saiga, Y., J. Cell. Comp. Physiol., 59, 223 (1962).
Edwards, C., Chichibu, S., and Hagiwara, S., J. Gen. Physiol., 48, 225 (1964).
Hagiwara, S., Takahashi, K., and Junge, D., J. Gen. Physiol., 51, 157 (1968).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
ASHLEY, C., RIDGWAY, E. Simultaneous Recording of Membrane Potential, Calcium Transient and Tension in Single Muscle Fibres. Nature 219, 1168–1169 (1968). https://doi.org/10.1038/2191168a0
Received:
Issue Date:
DOI: https://doi.org/10.1038/2191168a0
- Springer Nature Limited
This article is cited by
-
Regulation of myocardial contraction as revealed by intracellular Ca2+ measurements using aequorin
The Journal of Physiological Sciences (2024)
-
Monitoring neural activity with bioluminescence during natural behavior
Nature Neuroscience (2010)