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Oestrogen as Depressor of Noradrenaline Concentration in the Anterior Hypothalamus

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Abstract

THE concentration of hypothalamic noradrenaline changes during the oestrous cycle, and after castration in rats. During pro-oestrus and after castration, high values of noradrenaline are found. During oestrus the concentration of this amine in the rat anterior hypothalamus is low1,2. The ovarian hormones, oestradiol and progesterone, when administered simultaneously, reduce noradrenaline and increase dopamine in the anterior part of the hypothalamus of spayed rats practically to the levels found in normal oestrous rats3. This may mean that sex steroids exert a negative feedback influence on the adrenergic effectors in the hypothalamus.

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References

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Authors and Affiliations

  1. Instituto de Histología y Embriología, UNC Casilla de Correo 56, Mendoza, Argentina

    A. O. DONOSO & J. O. CUKIER

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  1. A. O. DONOSO
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  2. J. O. CUKIER
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DONOSO, A., CUKIER, J. Oestrogen as Depressor of Noradrenaline Concentration in the Anterior Hypothalamus. Nature 218, 969–970 (1968). https://doi.org/10.1038/218969a0

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  • DOI: https://doi.org/10.1038/218969a0

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