Skip to main content
SpringerLink
Log in

Electron Microscopy of Muscle Phosphorylase Molecules: Significance of a Rhombic Shape

  • Letter
  • Published:

From Nature

View current issue Submit your manuscript

Abstract

MUSCULAR energy comes from the breakdown of glycogen. This is not, however, the only reason for interest in the enzyme, muscle phosphorylase, which catalyses the first step in the reaction. The enzyme also provides one of the clearest examples of the way activity is related to change in molecular structure. Detailed accounts are available in various reviews1–3. The more pertinent facts, which have recently changed rather substantially, seem to be as follows.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Stadtman, E. R., Adv. Enzymol., 28, 41 (1966).

    CAS  PubMed  Google Scholar 

  2. Krebs, E. G., and Fischer, E. H., Adv. Enzymol., 24, 263 (1962).

    Google Scholar 

  3. Brown, D. H., and Cori, C. F., in The Enzymes, second ed. (edit. by Boyer, P. D., Lardy, H., and Myrback, K.), 5, 207 (Academic Press, New York and London, 1961).

    Google Scholar 

  4. Keller, P. J., J. Biol. Chem., 214, 135 (1955).

    CAS  PubMed  Google Scholar 

  5. Seery, V. L., Fischer, E. H., and Teller, D. C., Biochemistry, 6, 3315 (1967).

    Article  CAS  Google Scholar 

  6. Ullman, A., Vagelos, P. R., and Monod, J., Biochem. Biophys. Res. Commun., 17, 86 (1964).

    Article  CAS  Google Scholar 

  7. Wang, J. H., and Graves, D. J., Biochemistry, 3, 1437 (1964).

    Article  CAS  Google Scholar 

  8. Metzger, B., Helmreich, E., and Glaser, L., Proc. US Nat. Acad. Sci., 57, 994 (1967).

    Article  ADS  CAS  Google Scholar 

  9. Wang, J. H., and Graves, D. J., J. Biol. Chem., 238, 2386 (1963).

    CAS  PubMed  Google Scholar 

  10. Wang, J. H., Shonka, M. L., and Graves, D. J., Biochem. Biophys. Res. Commun., 18, 131 (1965).

    Article  CAS  Google Scholar 

  11. Lowry, O. H., Schulz, D. W., and Passonneau, J. V., J. Biol. Chem., 239, 1947 (1964).

    CAS  PubMed  Google Scholar 

  12. Chignell, D. A., Gratzer, W. B., and Valentine, R. C., Biochemistry, 7, 1082 (1968).

    Article  CAS  Google Scholar 

  13. Kent, A. B., Krebs, E. G., and Fischer, E. H., J. Biol. Chem., 232, 549 (1958).

    CAS  Google Scholar 

  14. Quiocho, F. A., and Richards, F. M., Proc. US Nat. Acad. Sci., 52, 833 (1964).

    Article  ADS  CAS  Google Scholar 

  15. Matthews, F. S., Fed. Proc., 26, 831 (1967).

    Google Scholar 

  16. Monod, J., Wyman, J., and Changeux, J. P., J. Mol. Biol., 12, 88 (1965).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. National Institute for Medical Research, Mill Hill, London

    ROBIN C. VALENTINE

  2. MRC Biophysics Research Unit, King's College, London

    DEREK A. CHIGNELL

Authors
  1. ROBIN C. VALENTINE
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. DEREK A. CHIGNELL
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

VALENTINE, R., CHIGNELL, D. Electron Microscopy of Muscle Phosphorylase Molecules: Significance of a Rhombic Shape. Nature 218, 950–953 (1968). https://doi.org/10.1038/218950c0

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1038/218950c0

  • Springer Nature Limited

This article is cited by

Search

Navigation