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Influenza Antibody in Human Respiratory Secretions after Subcutaneous or Respiratory Immunization with Inactivated Virus

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Abstract

STUDIES with human volunteers have shown that experimental infection with influenza virus is a better stimulus of antibody in respiratory secretions than is subcutaneous immunization with inactivated vaccine, although both procedures result in the production of similar concentrations of serum antibody1,2. The work reported here was undertaken to determine if administration of inactivated virus vaccine through the respiratory tract provokes a similar antibody response in respiratory secretions.

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References

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Authors and Affiliations

  1. Department of Microbiology, University of Florida College of Medicine, Gainesville, Florida

    ROBERT H. WALDMAN

  2. National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland

    JULIUS A. KASEL & ROBERT V. FULK

  3. Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland

    YASUSHI TOGO, RICHARD B. HORNICK, GORDON G. HEINER & ALBERT T. DAWKINS JUN.

  4. Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland

    JOHN J. MANN

Authors
  1. ROBERT H. WALDMAN
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  2. JULIUS A. KASEL
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  3. ROBERT V. FULK
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  4. YASUSHI TOGO
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  5. RICHARD B. HORNICK
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  6. GORDON G. HEINER
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  7. ALBERT T. DAWKINS JUN.
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  8. JOHN J. MANN
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WALDMAN, R., KASEL, J., FULK, R. et al. Influenza Antibody in Human Respiratory Secretions after Subcutaneous or Respiratory Immunization with Inactivated Virus. Nature 218, 594–595 (1968). https://doi.org/10.1038/218594a0

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  • DOI: https://doi.org/10.1038/218594a0

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