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Stimulation of Biosynthesis of Glyceride

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Abstract

The biosynthesis of glycerides from glycerolphosphate and palmitate, catalysed by mitochondrial and microsomal fractions, is greatly stimulated by the supernatant fraction (6,000,000×g-min). This is caused by the presence of a specific phosphatidate phosphohydrolase, unsaturated long-chain fatty acids and unspecific protein(s) in the supernatant fraction.

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References

  1. Kornberg, A., and Pricer, W. E., J. Biol. Chem., 204, 329 (1953).

    CAS  PubMed  Google Scholar 

  2. Kornberg, A., and Pricer, W. E., J. Biol. Chem., 204, 345 (1953).

    CAS  PubMed  Google Scholar 

  3. Senior, J. R., and Isselbacher, K. J., Biochim. Biophys. Acta, 44, 399 (1960).

    Article  CAS  PubMed  Google Scholar 

  4. Hokin, L. E., and Hokin, M. R., J. Gen. Physiol., 44, 51 (1961).

    Google Scholar 

  5. Goldman, P., and Vagelos, P. R., J. Biol. Chem., 236, 2620 (1961).

    CAS  PubMed  Google Scholar 

  6. Coleman, R., and Hübscher, G., Biochim. Biophys. Acta, 56, 479 (1962).

    Article  CAS  PubMed  Google Scholar 

  7. Johnston, J. M., and Bearden, J. H., Biochim. Biophys. Acta, 56, 365 (1962).

    Article  CAS  PubMed  Google Scholar 

  8. Senior, J. R., and Isselbacher, K. J., J. Biol. Chem., 237, 1454 (1962).

    CAS  PubMed  Google Scholar 

  9. Ailhaud, G., Samuel, D., and Desnuelle, P., Biochim. Biophys. Acta, 67, 150 (1963).

    Article  CAS  PubMed  Google Scholar 

  10. Hübscher, G., Clark, B., Webb, M. E., and Sherratt, H. S. A., in Biochemical Problems of Lipids (edit. by Fraser, A. C.), 201 (Elsevier, Amsterdam, 1963).

    Google Scholar 

  11. Wilgram, G. F., and Kennedy, E. P., J. Biol. Chem., 238, 2615 (1963).

    CAS  PubMed  Google Scholar 

  12. Brown, J. L., and Johnston, J. M., Biochim. Biophys. Acta, 84, 264 (1964).

    CAS  PubMed  Google Scholar 

  13. Korchak, H. M., and Masoro, E. J., Biochim. Biophys. Acta, 84, 750 (1964).

    CAS  PubMed  Google Scholar 

  14. Pynadath, T. I., and Kumar, S., Biochim. Biophys. Acta, 84, 251 (1964).

    CAS  PubMed  Google Scholar 

  15. Brindley, D. N., and Hübscher, G., Biochim. Biophys. Acta, 106, 495 (1965).

    Article  CAS  PubMed  Google Scholar 

  16. Sedgwick, B., and Hübscher, G., Biochim. Biophys. Acta, 106, 63 (1965).

    Article  CAS  PubMed  Google Scholar 

  17. Stein, Y., and Shapiro, B., Biochim. Biophys. Acta, 24, 197 (1957).

    Article  CAS  PubMed  Google Scholar 

  18. Stein, Y., Tietz, A., and Shapiro, B., Biochim. Biophys. Acta, 26, 286 (1957).

    Article  CAS  PubMed  Google Scholar 

  19. Hübscher, G., Smith, M. E., and Gurr, M. I., in Metabolism and Pnysiological Function of Lipids (edit. by Dawson, M. R. C., and Rhodes, D. N.), 299 (John Wiley, London, 1964).

    Google Scholar 

  20. Smith, M. E., and Hübscher, G., Biochem. J., 101, 306 (1966).

    Article  Google Scholar 

  21. Dils, R., and Clark, B., Biochem. J., 84, 19 (1962).

    Google Scholar 

  22. Roncari, D. A. K., and Hollenberg, C. H., Biochim. Biophys. Acta, 137, 446 (1967).

    Article  CAS  PubMed  Google Scholar 

  23. Johnston, J. M., Rao, G. A., Lowe, P. A., and Schwarz, B. E., Lipids, 2, 14 (1967).

    Article  CAS  PubMed  Google Scholar 

  24. Brindley, D. N., Smith, M. E., Sedgwick, B., and Hübscher, G., Biochim. Biophys. Acta, 144, 285 (1967).

    Article  CAS  PubMed  Google Scholar 

  25. Lands, W. E. M., and Hart, P., J. Lipid Res., 5, 81 (1964).

    CAS  PubMed  Google Scholar 

  26. Brindley, D. N., and Hübscher, G., Biochim. Biophys. Acta, 125, 92 (1966).

    Article  CAS  PubMed  Google Scholar 

  27. Young, R. J., and Garrett, R. L., J. Nutrit., 81, 321 (1963).

    CAS  PubMed  Google Scholar 

  28. Tzur, R., and Shapiro, B., J. Lipid Res., 5, 542 (1964).

    CAS  PubMed  Google Scholar 

  29. Lands, W. E. M., and Hart, P., J. Biol. Chem., 240, 1905 (1965).

    CAS  PubMed  Google Scholar 

  30. Smith, S. W., Weiss, S. B., and Kennedy, E. P., J. Biol. Chem., 228, 915 (1957).

    CAS  PubMed  Google Scholar 

  31. Smith, M. E., Sedgwick, B., Brindley, D. N., and Hübscher, G., Europ. J. Biochem. (in the press).

  32. Sedgwick, B., and Hübscher, G., Biochim. Biophys. Acta, 144, 397 (1967).

    Article  CAS  PubMed  Google Scholar 

  33. Farstad, M., Bremer, J., and Norum, K. R., Biochim. Biophys. Acta, 132, 492 (1967).

    Article  CAS  PubMed  Google Scholar 

  34. Farstad, M., Abstracts Fourth Meeting FEBS, Oslo, 55 (1967).

  35. Krebs, E. G., Love, D. S., Bratvold, G. E., Trayser, K. A., Meyer, W. L., and Fischer, E. D., Biochemistry, 3, 1022 (1964).

    Article  CAS  PubMed  Google Scholar 

  36. Bar-Tana, J., and Shapiro, B., Biochem. J., 93, 533 (1964).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  37. Ailhaud, G. P., and Vagelos, P. R., J. Biol. Chem., 241, 3866 (1966).

    CAS  PubMed  Google Scholar 

  38. Goldfine, H., J. Biol. Chem., 241, 3864 (1966).

    CAS  PubMed  Google Scholar 

Download references

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HÜBSCHER, G., BRINDLEY, D., SMITH, M. et al. Stimulation of Biosynthesis of Glyceride. Nature 216, 449–453 (1967). https://doi.org/10.1038/216449a0

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