Abstract
Estimation of the relative importance of platelets, lungs, liver and peripheral vascular beds in removing this amine from the circulation of the dog shows that the lungs are most active in this respect, and can remove more than 90 per cent in one circulation. This removal does not depend on monoamineoxidase activity.
Similar content being viewed by others
References
Humphrey, J. H., and Toh, C. C., J. Physiol., 124, 300 (1954).
Born, G. V. R., Day, M., and Stockbridge, A., J. Physiol. (in the press).
Weissbach, H., Bogdanski, D. F., and Udenfriend, S., Arch. Biochem., 73, 492 (1958).
Born, G. V. R., and Gillson, R. E., J. Physiol, 146, 472 (1959).
Lewis, G. P., J. Pharm. and Pharmacol., 10, 529 (1958).
Starling, E. H., and Verney, E. B., Proc. Roy. Soc., B, 97, 321 (1925).
Rapport, M. M., Green, A. A., and Page, I. H., J. Biol. Chem., 176, 1243 (1948).
Gaddum, J. H., Hebb, C. O., Silver, A., and Swan, A. A. B., Quart. J. Exp. Physiol., 38, 255 (1953).
Davis, R. B., and Wang, Y., Proc. Soc. Exp. Biol. and Med., 118, 797 (1965).
Drapanas, T., and McDonald, J. C., Surg. Gynec. and Obst., 116, 481 (1963).
Vane, J. R., Brit. J. Pharmacol. Chemotherap., 23, 360 (1964).
Vane, J. R., Brit. J. Pharmacol. Chemotherap., 12, 344 (1957).
Regoli, D., and Vane, J. R., J. Physiol., 183, 513 (1966).
Gaddum, J. H., Brit. J. Pharmacol. Chemotherap., 8, 321 (1953).
Paton, W. D. M., J. Physiol., 137, 35P (1957).
Brecher, G., and Cronkite, E. P., J. Appl. Physiol., 3, 365 (1950).
Hodge, R. L., Ng, K. K. F., and Vane, J. R., Nature, 215, 138 (1967).
Spinks, A., and Whittle, B. A., Intern. J. Neuropharmacol., 5, 125 (1966).
Stacey, R. S., in Heffer's Handbook of Experimental Pharmacology, 19, 744 (Berlin, 1966).
Duthie, H. L., and Irvine, W. T., in Scientific Basis of Surgery (edit. by Irvine, W. T.), 42 (Churchill, London, 1965).
Burks, T. F., and Long, J. P., Amer. J. Physiol., 211, 619 (1966).
Burks, T. F., and Long, J. P., J. Pharm. Sci., 55, 1383 (1966).
Drapanas, T., McDonald, J. C., and Stewart, J. D., Ann. Surg., 156, 528 (1962).
Peskin, G. W., and Miller, L. D., Arch. Surg., Chicago>, 85, 701 (1962).
Handschumacher, R. E., and Vane, J. R., Brit. J. Pharmacol. Chemotherap., 29, 105 (1967).
Gershon, M. D., and Ross, L. L., J. Physiol., 186, 477 (1966).
Kaufman, R. M., Airo, R., Pollack, S., and Crosby, W. H., Blood, 26, 720 (1965).
Thomas, D. P., Stein, M., Tanabe, G., Rege, V., and Wessler, S., Amer. J. Physiol., 206, 1207 (1964).
Stein, M., and Thomas, D. P., J. Appl. Physiol., 23, 47 (1967).
Colebatch, H. J. H., Olsen, C. R., and Nadel, J. A., J. Appl. Physiol., 21, 217 (1966).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
THOMAS, D., VANE, J. 5-Hydroxytryptamine in the Circulation of the Dog. Nature 216, 335–338 (1967). https://doi.org/10.1038/216335a0
Published:
Issue Date:
DOI: https://doi.org/10.1038/216335a0
- Springer Nature Limited
This article is cited by
-
Relationships among body mass, brain size, gut length, and blood tryptophan and serotonin in young wild-type mice
BMC Physiology (2009)
-
Origin of the blood hyperserotonemia of autism
Theoretical Biology and Medical Modelling (2008)
-
Statistical distribution of blood serotonin as a predictor of early autistic brain abnormalities
Theoretical Biology and Medical Modelling (2005)
-
Accumulation of platelets in the lung and liver and their degranulation following antigen‐challenge in sensitized mice
British Journal of Pharmacology (2002)
-
Platelets as participants in hyperacute guinea pig-to-rat lung xenorejection
Surgery Today (1999)