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Radiosensitization of Bacterial and Mammalian Cells by Substituted Glyoxals

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Abstract

Methylglyoxal preferentially sensitizes anoxic bacterial and mammalian cells to the lethal effects of ionizing radiation. The radio-protective effect of anoxia on mammalian cells is effectively abolished in the presence of methylglyoxal, whereas sensitization of oxygenated mammalian cells is slight.

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Author notes

  1. D. M. ROBINSON

    Present address: Microbiological Research Establishment, Porton Down, near Salisbury, Wiltshire

Authors and Affiliations

  1. Radiobiological Research Unit, Harwell, Didcot, Berkshire

    M. J. ASH WOOD-SMITH, D. M. ROBINSON, J. H. BARNES & BRYN A. BRIDGES

Authors
  1. M. J. ASH WOOD-SMITH
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  2. D. M. ROBINSON
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  3. J. H. BARNES
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  4. BRYN A. BRIDGES
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ASH WOOD-SMITH, M., ROBINSON, D., BARNES, J. et al. Radiosensitization of Bacterial and Mammalian Cells by Substituted Glyoxals. Nature 216, 137–139 (1967). https://doi.org/10.1038/216137a0

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  • DOI: https://doi.org/10.1038/216137a0

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