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Molecular Structure of p-Bromocarbobenzoxy-Glycyl-l-Prolyl-l-Leucyl-Glycine

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Abstract

WE have studied by X-ray analysis a series of oligopeptides, such as carbobenzoxy-Gly-Pro(OH), carbobenzoxy-Gly-Pro-Leu(OH), carbobenzoxy-Gly-Pro-Leu-Gly(OH) and carbobenzoxy-Gly-Pro-Leu-Gly-Pro(OH), which were prepared in order to examine the relationship between the structure of collagen and the substrate specificity for the enzyme reaction, of collagenase, and have already reported some of the results1–3. Recently, the three-dimensional analysis of the tetrapeptide, p-bromoearbo-benzoxy-Gly-Pro-Leu-Gly(OH), has been almost completed and a unique conformation was found in its structure.

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Authors and Affiliations

  1. Institute for Protein Research, Osaka University, Kita-ku, Osaka

    T. UEKI, T. ASHIDA & M. KAKUDO

  2. Faculty of Science, Tokyo Institute of Technology, Meguro-ku, Tokyo

    Y. SASADA

  3. Faculty of Engineering, Tottori University, Tottori

    Y. KATSUBE

Authors
  1. T. UEKI
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  2. T. ASHIDA
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  3. M. KAKUDO
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  4. Y. SASADA
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  5. Y. KATSUBE
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UEKI, T., ASHIDA, T., KAKUDO, M. et al. Molecular Structure of p-Bromocarbobenzoxy-Glycyl-l-Prolyl-l-Leucyl-Glycine. Nature 216, 1205–1207 (1967). https://doi.org/10.1038/2161205a0

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