Skip to main content
SpringerLink
Log in

Influence of the Injection of ‘Triton WR-1339’ on Lysosomes of a Rat Transplantable Hepatoma

  • Letter
  • Published:

From Nature

View current issue Submit your manuscript

Abstract

LYSOSOMES are subcellular particles in which several acid hydrolases of various specificities are localized. One of their main intracellular functions is to digest exogenous compounds taken up by the cell. The lysosomal system can be overloaded with substances which cannot be degraded, at least at a sufficient rate, by hydrolases1. This occurs in rat liver lysosomes2 and to some extent in kidney3 and spleen4 lysosomes after injection of ‘Triton WR-1339’, a non-ionic detergent. This compound is taken up by liver, kidney and spleen cells, and accumulates inside the lysosomes because it is not subjected to the lytic action of lysosomal enzymes. Accumulation causes increase in granular size and decrease in granular density.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. de Duve, C., and Wattiaux, R., Ann. Rev. Physiol., 28, 435 (1966).

    Article  CAS  Google Scholar 

  2. Wattiaux, R., Wibo, M., and Baudhuin, P., Ciba Found. Symp. Lysosomes, 176 (J. and A. Churchill, Ltd., London, 1963).

    Book  Google Scholar 

  3. Wattiaux-de Coninck, S., Rutgeerts, M. J., and Wattiaux, R., Biochim. Biophys. Acta, 105, 446 (1965).

    Article  CAS  Google Scholar 

  4. Bowers, W. E., and de Duve, C., J. Cell Biol., 32, 349 (1967).

    Article  CAS  Google Scholar 

  5. Wattiaux, R., in Etude Expérimentale de la Surcharge des Lysosomes (Imprimerie des éditions J. Duculot, S. A. Gembloux, Belgique, 1966).

    Google Scholar 

  6. Miller, G. W., and Janicki, B. W., Cancer Chemother. Rep., 39, 1 (1964).

    CAS  Google Scholar 

  7. Wattiaux, R., and Wattiaux-de Coninck, S., Europ. J. Cancer (in the press).

  8. Wattiaux, R., and Wattiaux-de Coninck, S., Europ. J. Cancer (in the press).

  9. Beaufay, H., Jacques, P., Baudhuin, P., Sellinger, O. Z., Berthet, J., and de Duve, C., Biochem. J., 92, 184 (1964).

    Article  CAS  Google Scholar 

  10. de Duve, C., Pressman, B. C., Gianetto, R., Wattiaux, R., and Appelmans, F., Biochem. J., 60, 604 (1955).

    Article  CAS  Google Scholar 

  11. Lowry, O. H., Rosebrough, N. J., Farr, A. L., and Randall, R. J., J. Biol. Chem., 193, 265 (1951).

    CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Laboratory of Physiological Chemistry, Facultés Universitaires, Notre Dame de la Paix, Namur, Belgium

    R. WATTIAUX & S. WATTIAUX-DE CONINCK

Authors
  1. R. WATTIAUX
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. S. WATTIAUX-DE CONINCK
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

WATTIAUX, R., WATTIAUX-DE CONINCK, S. Influence of the Injection of ‘Triton WR-1339’ on Lysosomes of a Rat Transplantable Hepatoma. Nature 216, 1132–1133 (1967). https://doi.org/10.1038/2161132a0

Download citation

  • Received:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/2161132a0

  • Springer Nature Limited

Search

Navigation