Skip to main content
SpringerLink
Log in

Concentrations of Pyruvate, Pyruvate Kinase and Lactate Dehydrogenase in the Kidney of the Alloxan-diabetic Rat

  • Letter
  • Published:

From Nature

View current issue Submit your manuscript

Abstract

INCREASED excretion of pyruvate has been observed in the urine of diabetic humans1 and rats2 which could not be correlated with blood pyruvate concentrations. This suggested that the increased excretion of pyruvate in diabetes was caused by altered kidney metabolism which in some way reduced the reabsorption of pyruvate in the kidney tubule. To investigate this possibility the concentrations of pyruvate and the activities of pyruvate kinase and lactate dehydrogenase are here reported in the kidney of the alloxan-diabetic rat and compared with the liver in the same condition.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Anderson, J., Comty, C. M., and Mazza, R., Lancet, ii, 1093 (1964).

  2. Anderson, J., Coulson, R., and Tomlinson, R. W. S., J. Physiol., 189, 237 (1967).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  3. Hohorst, H. J., Kreutz, F. H., and Bücher, T., Biochem. Z., 332, 18 (1959).

    CAS  PubMed  Google Scholar 

  4. Marks, V., Clin. Chim. Acta, 6, 724 (1961).

    Article  CAS  PubMed  Google Scholar 

  5. Bücher, T., and Pfleiderer, G., in Methods in Enzymology (edit. by Colowick, S. P., and Kaplan, N. O. ), 1, 435 (Academic Press, New York, 1955).

    Book  Google Scholar 

  6. Kornberg, A., in Methods of Enzymology (edit. by Colowick, S. P., and Kaplan, N. O. ), 1, 441 (Academic Press, New York, 1955).

    Book  Google Scholar 

  7. Lowry, O. H., Rosebrough, N. J., Farr, A. L., and Randall, R. J., J. Biol. Chem., 193, 265 (1951).

    CAS  PubMed  Google Scholar 

  8. Lamprecht, W., and Trautschold, I., Hoppe-Seyl. Z., 311, 245 (1958).

    Article  CAS  Google Scholar 

  9. Williamson, D. H., Lund, P., and Krebs, H. A., Biochem. J., 103, 514 (1967).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  10. Weber, G., Stamm, N. B., and Fisher, E. A., Science, 149, 65 (1965).

    Article  ADS  CAS  PubMed  Google Scholar 

  11. Weber, G., Lea, M. A., Fisher, E. A., and Stamm, N. B., Enzyme Biol. Clin., 7, 11 (1966).

    Article  CAS  Google Scholar 

  12. Krebs, H. A., and Eggleston, L. V., Biochem. J., 94, 3c (1965).

    Article  CAS  PubMed  Google Scholar 

  13. Tanaka, T., Horano, Y., Morimura, H., and Mori, R., Biochem. Biophys. Res. Commun., 21, 55 (1965).

    Article  CAS  PubMed  Google Scholar 

  14. Takeda, Y., Inoue, H., Honjo, K., Tanioka, H., and Daikuhara, Y., Biochim. Biophys. Acta, 136, 214 (1967).

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Medicine, King's College Hospital Medical School, London

    R. COULSON & J. ANDERSON

Authors
  1. R. COULSON
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. J. ANDERSON
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

COULSON, R., ANDERSON, J. Concentrations of Pyruvate, Pyruvate Kinase and Lactate Dehydrogenase in the Kidney of the Alloxan-diabetic Rat. Nature 215, 981–982 (1967). https://doi.org/10.1038/215981a0

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1038/215981a0

  • Springer Nature Limited

Search

Navigation