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Glucose-phosphorylating Enzyme with High Km in Human Brain

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Abstract

THE recent discovery of an insulin-inducible glucose-phosphorylating enzyme with high Km (“glucokinase”, ATP-D-glucose 6-phosphotransferase, E C 2.7.1.2.) in the liver1,2 and epididymal fat pad3 of small laboratory animals has added to the current interest in the mechanisms which control glucose metabolism in mammalian tissues. No evidence from kinetic studies4–6 or electrophoresis5,7, however, has yet been obtained for the occurrence of an analogous enzyme with high Km in the brains of rats, guinea-pigs or sheep and the view has grown that this type of activity is absent from the brain.

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Authors and Affiliations

  1. Department of Biochemistry, Institute of Psychiatry, The Maudsley Hospital, London

    H. S. BACHELARD

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  1. H. S. BACHELARD
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BACHELARD, H. Glucose-phosphorylating Enzyme with High Km in Human Brain. Nature 215, 959–960 (1967). https://doi.org/10.1038/215959a0

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