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Pituitary–Adrenal Regulation of Ceruloplasmin

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Abstract

INVESTIGATIONS of the effect of sex hormones on copper metabolism in man and animals have shown a sharp rise in ceruloplasmin after hormone injection1; however, the mechanism of this elevation has not previously been discussed. Hormonal control of the synthesis of RNA has been demonstrated (reviewed by Davidson2), and other investigations have shown that both testosterone and oestradiol can bind to DNA and stimulate RNA synthesis3. Ceruloplasmin is a protein and as such depends on RNA synthesis for its production. Molecules which act as inhibitors or stimulators of RNA synthesis could therefore control ceruloplasmin production.

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References

  1. Sass-Kortsak, A., in Advances in Clinical Chemistry (edit. by Sobatka, H., and Stewart, C. P.), 35 (Academic Press, 1965).

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Author notes

  1. G. W. EVANS

    Present address: Department of Biochemistry, University of North Dakota, Grand Forks, North Dakota

Authors and Affiliations

  1. Harmon Park Clinic Research Laboratory, Williston, North Dakota

    G. W. EVANS & R. E. WIEDERANDERS

Authors
  1. G. W. EVANS
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  2. R. E. WIEDERANDERS
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EVANS, G., WIEDERANDERS, R. Pituitary–Adrenal Regulation of Ceruloplasmin. Nature 215, 766–767 (1967). https://doi.org/10.1038/215766a0

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  • DOI: https://doi.org/10.1038/215766a0

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