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High Concentrations of Haemoglobin A2 in Malaria Patients

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Abstract

THE A2 fraction of normal haemoglobin (Hb-A2) has been described by Kunkel and Wallenius in 19551 and soon after it was confirmed that this fraction doubled its normal values or reached even greater concentrations in β-thalas-saemia minor2, and it has been found to be increased in pernicious anaemia in relapse3, in patients with Hb-Zürich4, in recipients of foetal haemopoietic tissue5 and in a single case of hereditary spherocytosis6. It is easy to exclude the last four conditions, and so greater concentrations of Hb-A2 than normal are considered specific for the diagnosis of β-thalassaemia minor.

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Authors and Affiliations

  1. Department of Experimental Haematology, Instituto Venezolano de Investigaciones Científicas, Caracas, Venezuela

    TULIO ARENDS

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  1. TULIO ARENDS
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ARENDS, T. High Concentrations of Haemoglobin A2 in Malaria Patients. Nature 215, 1517–1518 (1967). https://doi.org/10.1038/2151517a0

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  • DOI: https://doi.org/10.1038/2151517a0

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