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Some Serum Protein Nitrogen Mustard Complexes with High Chemotherapeutic Selectivity

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Abstract

THE use of proteins as carriers of cytotoxic groups has been put forward on several occasions, based on indications that some specificity of uptake is thereby achieved. Busch and Greene1 have shown that administration of radioactive albumin leads to the selective incorporation of radioactivity into tumours compared with other host tissues. Experimental evidence has also been advanced to show that radioactivity is localized selectively in tumours after administration of anti-fibrin antibody labelled with iodine-131 (ref. 2) and of similarly labelled fibrinogen3. This effect was more marked in the case of transplantable tumours than for spontaneous tumours but the results obtained provide a sound experimental basis for the use of this protein as a vehicle for the preferential introduction of cytotoxic agents.

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References

  1. Busch, H., and Greene, H. S. N., Yale J. Biol. Med., 27, 339 (1955).

    CAS  PubMed  PubMed Central  Google Scholar 

  2. Bale, W. F., Spar, I. L., and Goodland, R. L., Cancer Res., 20, 1488 (1960).

    CAS  PubMed  Google Scholar 

  3. Isliker, H., Cerottini, J. C., Jaton, J. C., and Magnenat, G., in Chemotherapy of Cancer (edit. by Plattner, P.), 278 (Elsevier, Amsterdam, 1964).

    Google Scholar 

  4. Bergel, F., Stock, J. A., and Wade, R., in Biological Approaches to Cancer Chemotherapy (edit. by Harris, R. J. C.), 125 (Academic Press, New York, 1961).

    Google Scholar 

  5. Larsen, B., Europ. J. Cancer, 2, 163 (1967).

    Article  Google Scholar 

  6. Tsou, K. G., and Su, H. C. F., J. Med. Chem. 6, 693 (1963).

    Article  CAS  Google Scholar 

  7. Fuchs, S., and Sela, M., J. Biol. Chem., 240, 3558 (1965).

    CAS  Google Scholar 

  8. Epstein, J., Rosenthal, R. W., and Ess, R. J., Anal. Chem., 27, 1435 (1955).

    Article  CAS  Google Scholar 

  9. Potter, M., and Robertson, C. L., J. Nat. Cancer Inst., 25, 847 (1960).

    Article  CAS  Google Scholar 

  10. Rosenoer, V. M., and Whisson, M. E., Biochem. Pharmacol., 13, 589–602 (1964).

    Article  CAS  Google Scholar 

  11. Connors, T. A., Jeney, A., and Whisson, M. E., Biochem. Pharmacol., 14, 1681 (1965).

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Chester Beatty Research Institute, Institute of Cancer Research, Royal Cancer Hospital, London

    ROY WADE & M. E. WHISSON

  2. Institute of Organic Chemistry, Eötvös Lorand University, Budapest

    MARIA SZEKERKE

Authors
  1. ROY WADE
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  2. M. E. WHISSON
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  3. MARIA SZEKERKE
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WADE, R., WHISSON, M. & SZEKERKE, M. Some Serum Protein Nitrogen Mustard Complexes with High Chemotherapeutic Selectivity. Nature 215, 1303–1304 (1967). https://doi.org/10.1038/2151303a0

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